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A method has been developed for quantification of bromhexine in plasma using gas chromatography mass spectrometry with selected ion monitoring. A deuterium labelled analogue was synthesized and used as the internal standard. To evaluate the gas chromatographic electron capture detection method described earlier, 23 plasma samples have been analysed by both techniques. Although a good correlation was shown, selected ion monitoring was superior to the electron capture detection method for levels below 3 ng ml-1. The mass spectrometric method has also been used to set up a pharmacokinetic study of bromhexine in horses. Urine extracts were subjected to gas chromatographic mass spectrometric analysis to identify the different metabolites of bromhexine. Three groups of metabolites were detected and identified.
J A Jonckheere, and
L M Thienpont, and
A P De Leenheer, and
P De Backer, and
M Debackere, and
F M Belpaire
June 1979,
Biomedical mass spectrometry,
J A Jonckheere, and
L M Thienpont, and
A P De Leenheer, and
P De Backer, and
M Debackere, and
F M Belpaire
June 1988,
Clinica chimica acta; international journal of clinical chemistry,
J A Jonckheere, and
L M Thienpont, and
A P De Leenheer, and
P De Backer, and
M Debackere, and
F M Belpaire
January 1987,
Journal of analytical toxicology,
J A Jonckheere, and
L M Thienpont, and
A P De Leenheer, and
P De Backer, and
M Debackere, and
F M Belpaire
October 1976,
Biomedical mass spectrometry,
J A Jonckheere, and
L M Thienpont, and
A P De Leenheer, and
P De Backer, and
M Debackere, and
F M Belpaire
October 1979,
Biomedical mass spectrometry,
J A Jonckheere, and
L M Thienpont, and
A P De Leenheer, and
P De Backer, and
M Debackere, and
F M Belpaire
January 1982,
Journal of chromatography,
J A Jonckheere, and
L M Thienpont, and
A P De Leenheer, and
P De Backer, and
M Debackere, and
F M Belpaire
August 1978,
Biomedical mass spectrometry,
J A Jonckheere, and
L M Thienpont, and
A P De Leenheer, and
P De Backer, and
M Debackere, and
F M Belpaire
July 1985,
Journal of chromatography,
J A Jonckheere, and
L M Thienpont, and
A P De Leenheer, and
P De Backer, and
M Debackere, and
F M Belpaire
April 1996,
Journal of chromatography. B, Biomedical applications,
J A Jonckheere, and
L M Thienpont, and
A P De Leenheer, and
P De Backer, and
M Debackere, and
F M Belpaire
October 1988,
Biomedical & environmental mass spectrometry,
