Biomaterial Database

Iron availability and absorption in rats fed sodium phytate. 1981

J E Hunter

Effects of dietary sodium phytate on iron availability and absorption in rats were assessed in two experiments. In the first experiment, iron-deficient rats were switched to diets containing variable levels of added sodium phytate and variable levels of iron as ferrous sulfate. Iron availability was evaluated by measuring hemoglobin regeneration after 2 weeks of feeding these diets. In the second experiment, both iron-adequate and iron-deficient rats were force-fed a slurry containing an iron-deficient diet, 59Fe and sodium phytate. Iron absorption was assessed by measuring the percentage of the 59Fe dose retained by the rats after 9 days. The results of the first experiment indicated that levels of dietary phytate up to 4% of the diet do not impair hemoglobin regeneration by anemic rats. The results of the second experiment indicated that sodium phytate does not affect iron absorption differently in iron-adequate rats compared to iron-deficient rats. It is suggested that conflicting results in the literature on effects of phytate on iron absorption may be explained by differences in experimental conditions or by the presence in the diet of some inhibitory component besides phytate, possibly dietary fiber.

UI	MeSH Term	Description	Entries
D007501	Iron	A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.	Iron-56,Iron 56
D008297	Male		Males
D010833	Phytic Acid	Complexing agent for removal of traces of heavy metal ions. It acts also as a hypocalcemic agent.	Inositol Hexaphosphate,Phytin,Calcium Phytate,Inositol Hexakisphosphate,Phytate,Sodium Phytate,Acid, Phytic,Hexakisphosphate, Inositol,Hexaphosphate, Inositol,Phytate, Calcium,Phytate, Sodium
D004032	Diet	Regular course of eating and drinking adopted by a person or animal.	Diets
D005296	Ferrous Compounds	Inorganic or organic compounds that contain divalent iron.	Compounds, Ferrous
D006452	Hemoglobinometry	Measurement of hemoglobin concentration in blood.	Hemoglobinometries
D000042	Absorption	The physical or physiological processes by which substances, tissue, cells, etc. take up or take in other substances or energy.
D000090463	Iron Deficiencies	Deficient amounts of iron in the body as a result of blood loss, diets deficient in iron, or an iron uptake or storage disorder.	Hypoferritinemia,Iron Deficiency,Latent Iron Deficiency,Sideropenia,Deficiencies, Iron,Deficiencies, Latent Iron,Deficiency, Iron,Deficiency, Latent Iron,Hypoferritinemias,Iron Deficiencies, Latent,Iron Deficiency, Latent,Latent Iron Deficiencies,Sideropenias
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001682	Biological Availability	The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.	Availability Equivalency,Bioavailability,Physiologic Availability,Availability, Biologic,Availability, Biological,Availability, Physiologic,Biologic Availability,Availabilities, Biologic,Availabilities, Biological,Availabilities, Physiologic,Availability Equivalencies,Bioavailabilities,Biologic Availabilities,Biological Availabilities,Equivalencies, Availability,Equivalency, Availability,Physiologic Availabilities