The values of central and regional hemodynamics were studied in 80 patients with hypertensive disease mainly of stage IIB by means of tetra- and bipolar rheography in different periods of treatment with obsidan, apressin and their combination. It was established that obsidan reduces the cardiac output and increases by reflex peripheral vascular resistance, while apressin reduces the vascular tonus and stimulates by reflex cardiac activity. Apressin caused a significant improvement in cerebral and peripheral circulation, but the asymmetry of cerebral and leg rheograms increased in these instances. In obsidan therapy the tonus of cerebral arteries diminished to a lesser degree while the tonus of the leg arteries was often increased, but the inter-hemispheric asymmetry of the rheoencephalogram and the limb rheograms diminished. The combined use of these drugs corrects undesirable effects in regard to the haemodynamic structure and potentiates the hypotensive effect.