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The experiments with rats treated with gentamicin showed that nitrogen excretion function of the kidneys did not significantly change in the animals 3 months after induction of pyelonephritis, while in the animals not treated with the antibiotic there was a significant increase in excretion of alkaline phosphatase with urine. The nitrogen excretion function of the kidneys was not affected by gentamicin, except an increase in the urea blood level. Gentamicin promoted a significant rise in excretion of enzymes with urine, especially that of alkaline phosphatase. Treatment of healthy animals with gentamicin resulted in the increased excretion of alkaline phosphatase with urine and increased urea blood levels which was evident of the nephrotoxic effect of the aminoglycoside antibiotic. When such animals were treated with furosemide, the renal excretion of the enzyme and the blood creatinine urea levels decreased. Therefore, furosemide lowered nephropathy induced by gentamicin. The increase in the activity of the urine enzymes may be due to inflammatory changes in the kidney parenchymal on the one hand and the pephrotoxic effect of the drugs on the other hand. The urine enzymes may be used as important diagnostic tests in cases with kidney affections and indicators of safe treatment with nephrotoxic antibiotics.
T Kh Shortanova, and
V A Kantariia, and
A M Kazakov, and
F M Gulieva, and
N I Samoĭlik
January 1968,
Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology,
T Kh Shortanova, and
V A Kantariia, and
A M Kazakov, and
F M Gulieva, and
N I Samoĭlik
October 1979,
Vrachebnoe delo,
T Kh Shortanova, and
V A Kantariia, and
A M Kazakov, and
F M Gulieva, and
N I Samoĭlik
November 1985,
Zeitschrift fur Urologie und Nephrologie,
T Kh Shortanova, and
V A Kantariia, and
A M Kazakov, and
F M Gulieva, and
N I Samoĭlik
January 1990,
International urology and nephrology,
T Kh Shortanova, and
V A Kantariia, and
A M Kazakov, and
F M Gulieva, and
N I Samoĭlik
January 1974,
Urologiia i nefrologiia,
T Kh Shortanova, and
V A Kantariia, and
A M Kazakov, and
F M Gulieva, and
N I Samoĭlik
March 1978,
Investigative urology,
T Kh Shortanova, and
V A Kantariia, and
A M Kazakov, and
F M Gulieva, and
N I Samoĭlik
January 1982,
International urology and nephrology,
T Kh Shortanova, and
V A Kantariia, and
A M Kazakov, and
F M Gulieva, and
N I Samoĭlik
April 1963,
The Journal of pathology and bacteriology,
T Kh Shortanova, and
V A Kantariia, and
A M Kazakov, and
F M Gulieva, and
N I Samoĭlik
January 1967,
Urologiia i nefrologiia,
T Kh Shortanova, and
V A Kantariia, and
A M Kazakov, and
F M Gulieva, and
N I Samoĭlik
January 1971,
Acta medica Scandinavica,
