Biomaterial Database

Photosensitization of Trichophyton with 8-methoxypsoralen to UV-A light radiation. 1981

T Horio, and S Watanabe

The photosensitization effect of 8-methoxypsoralen (8-MOP) and subsequent long-wavelength ultraviolet(UV-A) irradiation on Trichophyton mentagrophytes was examined by in vitro, semi-in vivo, and in vivo experiments. A marked fungicidal effect of 8-MOP plus UV-A (PUVA) on suspensions of fungal spores was observed in vitro as measured by loss in colony-forming ability of T. mentagrophytes. 8-MOP application or UV-A irradiation alone did not show such an ability. The antifungal effect of PUVA was also observed on the infected scales obtained from experimental and clinical dermatophytosis. The in vivo activity of PUVA treatments was also demonstrated on the lesions of experimentally induced dermatophytosis in guinea-pigs. These observations suggest possible clinical applications of photochemotherapy on superficial fungal infections.

UI	MeSH Term	Description	Entries
D008730	Methoxsalen	A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.	8-Methoxypsoralen,Ammoidin,Xanthotoxin,8-MOP,Deltasoralen,Dermox,Geroxalen,Meladinina,Meladinine,Meloxine,Methoxa-Dome,Méladinine,Oxsoralen,Oxsoralen-Ultra,Puvalen,Ultramop,8 MOP,8 Methoxypsoralen,8MOP,Methoxa Dome,Oxsoralen Ultra
D010778	Photochemotherapy	Therapy using oral or topical photosensitizing agents with subsequent exposure to light.	Blue Light Photodynamic Therapy,Photodynamic Therapy,Red Light PDT,Red Light Photodynamic Therapy,Therapy, Photodynamic,Light PDT, Red,PDT, Red Light,Photochemotherapies,Photodynamic Therapies,Therapies, Photodynamic
D011701	PUVA Therapy	Photochemotherapy using PSORALENS as the photosensitizing agent and ultraviolet light type A (UVA).	Psoralen Ultraviolet A Therapy,Therapy, PUVA,PUVA Therapies,Therapies, PUVA
D006168	Guinea Pigs	A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.	Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014005	Tinea	Fungal infection of keratinized tissues such as hair, skin and nails. The main causative fungi include MICROSPORUM; TRICHOPHYTON; and EPIDERMOPHYTON.	Dermatophytoses,Epidermophytosis,Ringworm,Tinea Corporis,Trichophytosis,Dermatophytosis,Trichophyton mentagrophytes Infection,Epidermophytoses,Infection, Trichophyton mentagrophytes,Tineas,Trichophyton mentagrophytes Infections,Trichophytoses
D014249	Trichophyton	A mitosporic fungal genus and an anamorphic form of Arthroderma. Various species attack the skin, nails, and hair.	Endodermophyton,Trychophyton,Endodermophytons,Trichophytons,Trychophytons
D014466	Ultraviolet Rays	That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.	Actinic Rays,Black Light, Ultraviolet,UV Light,UV Radiation,Ultra-Violet Rays,Ultraviolet Light,Ultraviolet Radiation,Actinic Ray,Light, UV,Light, Ultraviolet,Radiation, UV,Radiation, Ultraviolet,Ray, Actinic,Ray, Ultra-Violet,Ray, Ultraviolet,Ultra Violet Rays,Ultra-Violet Ray,Ultraviolet Black Light,Ultraviolet Black Lights,Ultraviolet Radiations,Ultraviolet Ray