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The pharmacokinetics of amikacin was studied in 17 hospitalized patients with normal renal function (creatinine clearance greater than 90 ml/min), after the administration of a single dose of 7.5 mg/kg body weight. In 10 patients the antibiotic was administered intravenously and in the other 7 it was injected intramuscularly. After i.v. administration, the antibiotic followed an open two-compartment kinetic model, and after i.m. administration it followed a single compartment kinetic model. The route of administration did not significantly modify the pharmacokinetic parameters of amikacin. On the basis of the pharmacokinetic parameters thus established, an intravenous infusion for therapeutic use should have an administration rate of 2.5 [mg/kg/h] and a duration of 6 h.
J M Lanao, and
A Dominguez-Gil, and
J M Tabernero, and
L Corbacho
December 1983,
Journal of pharmacokinetics and biopharmaceutics,
J M Lanao, and
A Dominguez-Gil, and
J M Tabernero, and
L Corbacho
December 2013,
Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia,
J M Lanao, and
A Dominguez-Gil, and
J M Tabernero, and
L Corbacho
September 1989,
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J M Lanao, and
A Dominguez-Gil, and
J M Tabernero, and
L Corbacho
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J M Lanao, and
A Dominguez-Gil, and
J M Tabernero, and
L Corbacho
January 1988,
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J M Lanao, and
A Dominguez-Gil, and
J M Tabernero, and
L Corbacho
January 2015,
Chirality,
J M Lanao, and
A Dominguez-Gil, and
J M Tabernero, and
L Corbacho
January 1991,
Fundamental & clinical pharmacology,
J M Lanao, and
A Dominguez-Gil, and
J M Tabernero, and
L Corbacho
June 1987,
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J M Lanao, and
A Dominguez-Gil, and
J M Tabernero, and
L Corbacho
October 1982,
Pediatric research,
J M Lanao, and
A Dominguez-Gil, and
J M Tabernero, and
L Corbacho
March 1992,
Methods and findings in experimental and clinical pharmacology,
