Biomaterial Database

Inhibition by dexamethasone of erythropoietin-induced amplification of the erythropoietin-responsive cell compartment. 1981

M J Giglio, and R M Alippi, and C E Bozzini

Erythropoietin-responsive cells (ERC) were reduced to very low levels in post-hypoxic polycythemic mice by intraperitoneal injection of 60 mg/kg-mouse of busulfan. Repeated injections of 5 units erythropoietin (Ep), 1, 2, and 3 days after busulfan repopulated the ERC compartment. Therefore, injection of a small test dose of Ep on day 5 induced a considerable wave of erythropoiesis. When busulfan-treated polycythemic mice received 5 mg of dexamethasone together with Ep injections they responded to the test dose of Ep with very minor increases in iron incorporation, which would indicate that a very small increase in the ERC population induced by Ep took place. These results suggest that the inhibitory action of dexamethasone on erythropoiesis is exerted not only by inhibiting the Ep-induced differentiation of ERC into proerythroblasts, but also by inhibiting the effect of the hormone on the amplification of the ERC compartment.

UI	MeSH Term	Description	Entries
D007504	Iron Radioisotopes	Unstable isotopes of iron that decay or disintegrate emitting radiation. Fe atoms with atomic weights 52, 53, 55, and 59-61 are radioactive iron isotopes.	Radioisotopes, Iron
D011086	Polycythemia	An increase in the total red cell mass of the blood. (Dorland, 27th ed)	Erythrocytosis,Erythrocytoses,Polycythemias
D002066	Busulfan	An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.	Busulphan,Busulfan Wellcome,Busulfex,Glyzophrol,Myelosan,Mylecytan,Myleran,Myléran,n-Butane-1,3-di(methylsulfonate),Wellcome, Busulfan
D003907	Dexamethasone	An anti-inflammatory 9-fluoro-glucocorticoid.	Hexadecadrol,Decaject,Decaject-L.A.,Decameth,Decaspray,Dexasone,Dexpak,Hexadrol,Maxidex,Methylfluorprednisolone,Millicorten,Oradexon,Decaject L.A.
D004912	Erythrocytes	Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.	Blood Cells, Red,Blood Corpuscles, Red,Red Blood Cells,Red Blood Corpuscles,Blood Cell, Red,Blood Corpuscle, Red,Erythrocyte,Red Blood Cell,Red Blood Corpuscle
D004920	Erythropoiesis	The production of red blood cells (ERYTHROCYTES). In humans, erythrocytes are produced by the YOLK SAC in the first trimester; by the liver in the second trimester; by the BONE MARROW in the third trimester and after birth. In normal individuals, the erythrocyte count in the peripheral blood remains relatively constant implying a balance between the rate of erythrocyte production and rate of destruction.	Erythropoieses
D004921	Erythropoietin	Glycoprotein hormone, secreted chiefly by the KIDNEY in the adult and the LIVER in the FETUS, that acts on erythroid stem cells of the BONE MARROW to stimulate proliferation and differentiation.
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor