To investigate the relationships between several neuropsychological deficits and personality function, 73 schizophrenic subjects with medically verified brain damage were administered the Luria-Nebraska Neuropsychological Battery (L-N) and the MMPI. Relationships between each of the 14 neuropsychological variables (the fourteen summary scales of the L-N) and each of the 10 clinical and three validity scales of the MMPI were analyzed by means of t-tests and Pearson correlations. Complex relationships between the neuropsychological variables and the MMPI scales were analyzed by means of multiple regression and discriminant analysis. With the exception of the F scale, results showed a relative lack of individual relationships between the cognitive and personality variables. As expected, however, relatively strong correlations were found between neuropsychological performance and overall patterns of personality variables for 11 of the 14 neuropsychological variables. Traditional personality differences associated with lesion laterality were replicated. Personality profiles uniquely related to specific neuropsychological deficits and personality trends which appeared across neuropsychological variables were discussed in terms of psychological reactivity and cognitive loss.