Biomaterial Database

Metabolism of 1,3-dibromopropane. 1981

S P James, and M A Pue, and D H Richards

Oral administration of 1,3-dibromopropane (2 mmol/kg) to rats resulted in a marked decrease in the level of hepatic glutathione (GSH). Sulphur-containing [14C]-metabolites were excreted in the bile of rats dose with 1,3-bromo[14C]propane and were subjected to enterohepatic cycling. After an oral dose of 1,3-dibromo[14C]propane, peak levels of radioactivity were rapidly attained in the blood and were maintained for several hours; approximately equal amounts of radioactive material were excreted in urine and expired air. Several radioactive metabolites were excreted in urine; a major metabolite was N-acetyl-S-[1-bromo-3-propyl]-cysteine.

UI	MeSH Term	Description	Entries
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D011407	Propane	A three carbon alkane with the formula H3CCH2CH3.
D002250	Carbon Radioisotopes	Unstable isotopes of carbon that decay or disintegrate emitting radiation. C atoms with atomic weights 10, 11, and 14-16 are radioactive carbon isotopes.	Radioisotopes, Carbon
D005978	Glutathione	A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.	Reduced Glutathione,gamma-L-Glu-L-Cys-Gly,gamma-L-Glutamyl-L-Cysteinylglycine,Glutathione, Reduced,gamma L Glu L Cys Gly,gamma L Glutamyl L Cysteinylglycine
D006842	Hydrocarbons, Brominated	Hydrocarbon compounds with one or more HYDROGEN atoms substituted with BROMINE.	Brominated Hydrocarbons
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001646	Bile	An emulsifying agent produced in the LIVER and secreted into the DUODENUM. Its composition includes BILE ACIDS AND SALTS; CHOLESTEROL; and ELECTROLYTES. It aids DIGESTION of fats in the duodenum.	Biliary Sludge,Sludge, Biliary
D001711	Biotransformation	The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus