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To determine whether alterations in the mechanical properties (i.e., stiffening) of the right and left ventricles contribute to the decrease in right and left ventricular end-diastolic volumes during continuous positive-pressure ventilation (CPPV), we studied six dogs anesthetized with chloralose urethane and ventilated with a volume ventilator. We varied ventricular volumes by withdrawing or infusing blood. Pressure-volume curves, constructed by plotting transmural ventricular end-diastolic pressures against ventricular end-diastolic volumes, did not change during CPPV (12 cmH2O positive end-expiratory pressure) compared to intermittent positive-pressure ventilation (IPPV, 0 cmH2O end-expiratory pressure). We conclude that decreased ventricular end-diastolic volumes during CPPV result primarily from a decrease in venous return. Alterations in the mechanical properties of the ventricles do not play a significant role in this response.
J E Fewell, and
D R Abendschein, and
C J Carlson, and
E Rapaport, and
J F Murray
February 1986,
Anesthesiology,
J E Fewell, and
D R Abendschein, and
C J Carlson, and
E Rapaport, and
J F Murray
August 1972,
Annals of internal medicine,
J E Fewell, and
D R Abendschein, and
C J Carlson, and
E Rapaport, and
J F Murray
October 2009,
Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc,
J E Fewell, and
D R Abendschein, and
C J Carlson, and
E Rapaport, and
J F Murray
July 2001,
Journal of applied physiology (Bethesda, Md. : 1985),
J E Fewell, and
D R Abendschein, and
C J Carlson, and
E Rapaport, and
J F Murray
December 2010,
Seminars in cardiothoracic and vascular anesthesia,
J E Fewell, and
D R Abendschein, and
C J Carlson, and
E Rapaport, and
J F Murray
February 1995,
Revista clinica espanola,
J E Fewell, and
D R Abendschein, and
C J Carlson, and
E Rapaport, and
J F Murray
March 1981,
Resuscitation,
J E Fewell, and
D R Abendschein, and
C J Carlson, and
E Rapaport, and
J F Murray
December 2023,
Journal of perinatology : official journal of the California Perinatal Association,
J E Fewell, and
D R Abendschein, and
C J Carlson, and
E Rapaport, and
J F Murray
February 1990,
Journal of applied physiology (Bethesda, Md. : 1985),
J E Fewell, and
D R Abendschein, and
C J Carlson, and
E Rapaport, and
J F Murray
June 1990,
Surgery, gynecology & obstetrics,
