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[Effect of alloxan diabetes on the enzyme activity of the mucous membrane of the small intestine]. 1978

K R Rakhimov, and B Z Zaripov

Experiments on male rats showed that following subcutaneous injection of alloxan in a dose of 15 mg per 100 g of body weight amylolytic, invertase, glycyl-l-tyrosine dipeptidehydrolase activity of the mucosa of the small intestine altered differently. As a result, there occurred a deviation of the enzymatic spectrum from the normal characterized by a sharp increase (with the development of diabetes) of the activity of the carbohydrate hydrolysing enzymes (amylase and invertase) with a simultaneous reduction of the activity of the enzymes participating in protein (dipeptidase) and fat (monglyceridlipase) hydrolysis.

UI MeSH Term Description Entries
D007413 Intestinal Mucosa Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI. Intestinal Epithelium,Intestinal Glands,Epithelium, Intestinal,Gland, Intestinal,Glands, Intestinal,Intestinal Gland,Mucosa, Intestinal
D008297 Male Males
D008994 Monoacylglycerol Lipases An enzyme that catalyzes the hydrolysis of glycerol monoesters of long-chain fatty acids EC 3.1.1.23. Glycerol Monoester Hydrolase,Glycerol Monoester Hydrolases,Monoacylglycerol Lipase,Monoglyceride Esterase,Monoglyceride Esterases,Monoglyceride Lipase,Monoglyceride Lipases,Monoglyceride Hydrolase,Esterase, Monoglyceride,Esterases, Monoglyceride,Hydrolase, Glycerol Monoester,Hydrolase, Monoglyceride,Hydrolases, Glycerol Monoester,Lipase, Monoacylglycerol,Lipase, Monoglyceride,Lipases, Monoacylglycerol,Lipases, Monoglyceride,Monoester Hydrolase, Glycerol,Monoester Hydrolases, Glycerol
D003921 Diabetes Mellitus, Experimental Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY. Alloxan Diabetes,Streptozocin Diabetes,Streptozotocin Diabetes,Experimental Diabetes Mellitus,Diabete, Streptozocin,Diabetes, Alloxan,Diabetes, Streptozocin,Diabetes, Streptozotocin,Streptozocin Diabete
D004150 Dipeptidases EXOPEPTIDASES that specifically act on dipeptides. EC 3.4.13.
D000496 Alloxan Acidic compound formed by oxidation of URIC ACID. It is isolated as an efflorescent crystalline hydrate.
D000681 Amylases A group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans. (Stedman, 25th ed) EC 3.2.1.-. Diastase,Amylase
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013393 Sucrase Digestive enzyme secreted in the INTESTINES. It catalyzes hydrolysis of SUCROSE to FRUCTOSE and GLUCOSE. Mutansucrase,Sucrose alpha-D-Glucohydrolase,Sucrose alpha D Glucohydrolase,alpha-D-Glucohydrolase, Sucrose
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor

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