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Effect of liquid additives on release of chloramphenicol from ointment bases. 1978

A H Ghanem, and H M El-Sabbagh, and A M El-Helw

1, 3 and 5% water, ethyl alcohol, glycerol and propylene glycol were incorporated into oleaginous, absorption, emulsion (O/W and W/O) and water-soluble ointment bases (resp.) containing 5% of chloramphenicol and diffusion rate via the dialysis method was measured for 2 h. The rate of release was found to be greater from water-soluble bases than from the other bases, since rates from oleaginous, absorption and W/O emulsion bases were found to be the least in this respect. The effect of liquids added to these bases on drug release was found to be less pronounced than that obtained with water-soluble and O/W emulsion bases. For O/W emulsion bases the addition of ethyl alcohol increased the release of chloramphenicol as its concentration was increased. Propylene glycol increased the release at a concentration of 3%, but higher concentration produced opposite results. Glycerol was found to have a little effect in 5% concentration, but it increased the release as the concentration dropped to 3% concentration.

UI MeSH Term Description Entries
D007809 Lanolin A yellow fat obtained from sheep's wool. It is used as an emollient, cosmetic, and pharmaceutic aid.
D009823 Ointment Bases Various mixtures of fats, waxes, animal and plant oils and solid and liquid hydrocarbons; vehicles for medicinal substances intended for external application; there are four classes: hydrocarbon base, absorption base, water-removable base and water-soluble base; several are also emollients. Bases, Ointment
D010232 Paraffin A mixture of solid hydrocarbons obtained from petroleum. It has a wide range of uses including as a stiffening agent in ointments, as a lubricant, and as a topical anti-inflammatory. It is also commonly used as an embedding material in histology. Parafilm
D002701 Chloramphenicol An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106) Cloranfenicol,Kloramfenikol,Levomycetin,Amphenicol,Amphenicols,Chlornitromycin,Chlorocid,Chloromycetin,Detreomycin,Ophthochlor,Syntomycin
D004655 Emulsions Colloids formed by the combination of two immiscible liquids such as oil and water. Lipid-in-water emulsions are usually liquid, like milk or lotion. Water-in-lipid emulsions tend to be creams. The formation of emulsions may be aided by amphiphatic molecules that surround one component of the system to form MICELLES. Emulsion
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor

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