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Two cases of primitive malignant tumour of the duodenum are reported, with exclusion of neoplasias of the periampullar region. Such restriction makes this pathology rather rare. The clinico-diagnostic aspects are analysed and, for purpose of radicality, a comparison is made between two surgical techniques: duodenocephalopancreatectomy, possible for any localisation, and intestinal shortening with duodenal-jejunal resection for tumours of the 3rd and 4th portions.
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