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Acute liver injury was induced experimentally in rats by a single injection of a large amount of D-galactosamine. Hepatocellular damage was apparent from decrease of total serum proteins, marked release of transaminases into the circulation, precipitous decrease of total microsomal proteins, and intracellular enzymes such as cytochrome P450 and 5'-nucleotidase. In parallel with such hepatocellular damage, serum asialoglycoproteins accumulated markedly, reaching a maximum level 4 days after the injection and then decreased to the control level. In contrast to this increase, hepatic binding protein, a receptor in the liver which specifically recognizes asialoglycoproteins, decreased very much. At the same time, survival time of [125I]asialoorosomucoid intravenously administered into rats was much prolonged in inverse proportion to the decrease of the binding protein. From these results it was concluded that the decrease of the hepatic binding protein induced by galactosamine treatment is probably responsible for the marked accumulation of serum asialoglycoproteins.
T Sawamura, and
S Kawasato, and
Y Shiozaki, and
Y Sameshima, and
H Nakada, and
Y Tashiro
December 1976,
The Journal of biological chemistry,
T Sawamura, and
S Kawasato, and
Y Shiozaki, and
Y Sameshima, and
H Nakada, and
Y Tashiro
February 1979,
The Journal of biological chemistry,
T Sawamura, and
S Kawasato, and
Y Shiozaki, and
Y Sameshima, and
H Nakada, and
Y Tashiro
January 1981,
Journal of biochemistry,
T Sawamura, and
S Kawasato, and
Y Shiozaki, and
Y Sameshima, and
H Nakada, and
Y Tashiro
July 1994,
Molecular and cellular biochemistry,
T Sawamura, and
S Kawasato, and
Y Shiozaki, and
Y Sameshima, and
H Nakada, and
Y Tashiro
September 1976,
The Journal of biological chemistry,
T Sawamura, and
S Kawasato, and
Y Shiozaki, and
Y Sameshima, and
H Nakada, and
Y Tashiro
April 1980,
The Journal of biological chemistry,
T Sawamura, and
S Kawasato, and
Y Shiozaki, and
Y Sameshima, and
H Nakada, and
Y Tashiro
August 1979,
Diabetologia,
T Sawamura, and
S Kawasato, and
Y Shiozaki, and
Y Sameshima, and
H Nakada, and
Y Tashiro
September 1974,
The Journal of biological chemistry,
T Sawamura, and
S Kawasato, and
Y Shiozaki, and
Y Sameshima, and
H Nakada, and
Y Tashiro
May 1976,
Journal of toxicology and environmental health,
T Sawamura, and
S Kawasato, and
Y Shiozaki, and
Y Sameshima, and
H Nakada, and
Y Tashiro
October 1978,
Hoppe-Seyler's Zeitschrift fur physiologische Chemie,
