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We have investigated the time course of formation of thromboxane A2, thromboxane B2, and the C-17 hydroxy fatty acid, HHT, from arachidonic acid in a washed human platelet suspension. Our results indicate that HHT is not a breakdown product of thromboxane A2, but rather thromboxane A2 decomposes exclusively into thromboxane B2. The kinetics of formation of thromboxane B2 from the endoperoxide prostaglandin H2 in human platelet microsomes was examined. Our data suggest that a bimolecular reaction is involved in the formation of thromboxane A2 from prostaglandin H2 and that thromboxane synthase is not an isomerase, but may be acting via a dismutase-type reaction. One possibility is that thromboxane and HHT are produced simultaneously from two molecules of prostaglandin H2.
M W Anderson, and
D J Crutchley, and
B E Tainer, and
T E Eling
September 1977,
Proceedings of the National Academy of Sciences of the United States of America,
M W Anderson, and
D J Crutchley, and
B E Tainer, and
T E Eling
January 1995,
Advances in prostaglandin, thromboxane, and leukotriene research,
M W Anderson, and
D J Crutchley, and
B E Tainer, and
T E Eling
January 1980,
Advances in prostaglandin and thromboxane research,
M W Anderson, and
D J Crutchley, and
B E Tainer, and
T E Eling
January 1981,
Progress in lipid research,
M W Anderson, and
D J Crutchley, and
B E Tainer, and
T E Eling
January 1976,
Advances in prostaglandin and thromboxane research,
M W Anderson, and
D J Crutchley, and
B E Tainer, and
T E Eling
July 1992,
FEBS letters,
M W Anderson, and
D J Crutchley, and
B E Tainer, and
T E Eling
February 1987,
Experimental eye research,
M W Anderson, and
D J Crutchley, and
B E Tainer, and
T E Eling
May 1980,
Microvascular research,
M W Anderson, and
D J Crutchley, and
B E Tainer, and
T E Eling
November 1977,
Biochemical and biophysical research communications,
M W Anderson, and
D J Crutchley, and
B E Tainer, and
T E Eling
January 1985,
Advances in prostaglandin, thromboxane, and leukotriene research,
