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In 75 healthy HBsAg carriers with normal liver tissue who were followed over a four years period, anti-HBc IgM was determined by ELISA. 61 HBsAg carriers (81%) were positive for anti-HBc IgM at first investigation. 54 individuals demonstrated persistence of anti-HBc IgM, 7 became anti-HBc IgM-negative within the observation period. 12 persons were persistent anti-HBc IgM of low quantities. 3 of 4 individuals with HBsAg clearance demonstrated a considerable decrease of anti-HBc IgM concentration. Although signs of liver damage or development of chronic liver diseases were not observed at the time of control biopsy the existence of anti-HBcIgM indicates that there exists also in healthy HBsAg carriers a persistent stimulation by HBcAg, inducing the production of anti-HBc IgM as a sign of permanent ongoing virus B replication. These results require a new and critical review of the "healthy" HBsAg carrier state.
H H Dromeyer, and
W Arnold, and
P Kryger, and
J O Nielsen, and
K H Meyer zum Büschenfelde
October 1983,
British medical journal (Clinical research ed.),
H H Dromeyer, and
W Arnold, and
P Kryger, and
J O Nielsen, and
K H Meyer zum Büschenfelde
March 1986,
Journal of medical virology,
H H Dromeyer, and
W Arnold, and
P Kryger, and
J O Nielsen, and
K H Meyer zum Büschenfelde
August 1976,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
H H Dromeyer, and
W Arnold, and
P Kryger, and
J O Nielsen, and
K H Meyer zum Büschenfelde
September 2021,
Hepatology forum,
H H Dromeyer, and
W Arnold, and
P Kryger, and
J O Nielsen, and
K H Meyer zum Büschenfelde
January 1989,
Infection,
H H Dromeyer, and
W Arnold, and
P Kryger, and
J O Nielsen, and
K H Meyer zum Büschenfelde
November 2011,
Virology journal,
H H Dromeyer, and
W Arnold, and
P Kryger, and
J O Nielsen, and
K H Meyer zum Büschenfelde
January 1992,
Archives of virology. Supplementum,
H H Dromeyer, and
W Arnold, and
P Kryger, and
J O Nielsen, and
K H Meyer zum Büschenfelde
June 1985,
Medicina clinica,
H H Dromeyer, and
W Arnold, and
P Kryger, and
J O Nielsen, and
K H Meyer zum Büschenfelde
July 1982,
Deutsche medizinische Wochenschrift (1946),
H H Dromeyer, and
W Arnold, and
P Kryger, and
J O Nielsen, and
K H Meyer zum Büschenfelde
January 1982,
Acta medica Academiae Scientiarum Hungaricae,
