Clinical observation of two cases with a particular type of Foville's syndrome appears to confirm physiological data from many experimental studies on the paramedian pontine reticular formation (PPRF). The nature of the oculomotor syndrome, which was confirmed by electrooculographic recordings, together with the analysis of pathognomonic features, suggested the existence of limited unilateral pontine lesions involving the formation. Rather than relying on subtle differences in ocular reflex signs it should be noted that each PPRF produces all homolateral saccades and controls pursuit eye movements in both directions, though only in the homolateral hemifield of eye movements.