-transparent.png){kind=logo}
The authors report the results of a study of 139 of their patients with severe rheumatoid arthritis, treated with chlorambucil of cyclophosphamide between 1965 and December 1973, with an observation period of 4 to 12 years. 8 patients were lost to follow-up, 38 died and 93 were reexamined. In this series 7 deaths were attributed to hemolymphoreticulopathy of various cytological types; 6 deaths were due to visceral cancer and 2 others to cancer of the tonsils. They confirm that such treatments increase the risk of hemopathy but apparently not the risk of visceral cancer. The risk was not a function of the total dose of the drug administered since no neoplasia was observed in the 25 subjects who received the highest doses. The addition of chlorambucil to cyclophosphamide seems to increase the risk of hemopathy. It was noticed that the 7 cases of hemolymphoreticulopathy occured after 60 years.
J C Renier, and
C Bregeon, and
C Bonnette, and
M Boasson, and
M Bernat, and
M Basle, and
J Besson, and
C Wellinger, and
B Bourgeois, and
N Teisseire
August 1973,
Minerva medica,
J C Renier, and
C Bregeon, and
C Bonnette, and
M Boasson, and
M Bernat, and
M Basle, and
J Besson, and
C Wellinger, and
B Bourgeois, and
N Teisseire
January 1972,
Reumatologia,
J C Renier, and
C Bregeon, and
C Bonnette, and
M Boasson, and
M Bernat, and
M Basle, and
J Besson, and
C Wellinger, and
B Bourgeois, and
N Teisseire
January 1970,
Reumatismo,
J C Renier, and
C Bregeon, and
C Bonnette, and
M Boasson, and
M Bernat, and
M Basle, and
J Besson, and
C Wellinger, and
B Bourgeois, and
N Teisseire
January 1995,
Materia medica Polona. Polish journal of medicine and pharmacy,
J C Renier, and
C Bregeon, and
C Bonnette, and
M Boasson, and
M Bernat, and
M Basle, and
J Besson, and
C Wellinger, and
B Bourgeois, and
N Teisseire
November 2005,
Arthritis and rheumatism,
J C Renier, and
C Bregeon, and
C Bonnette, and
M Boasson, and
M Bernat, and
M Basle, and
J Besson, and
C Wellinger, and
B Bourgeois, and
N Teisseire
September 1971,
The Journal of the Medical Society of New Jersey,
J C Renier, and
C Bregeon, and
C Bonnette, and
M Boasson, and
M Bernat, and
M Basle, and
J Besson, and
C Wellinger, and
B Bourgeois, and
N Teisseire
November 2002,
Annals of the rheumatic diseases,
J C Renier, and
C Bregeon, and
C Bonnette, and
M Boasson, and
M Bernat, and
M Basle, and
J Besson, and
C Wellinger, and
B Bourgeois, and
N Teisseire
February 1987,
The Journal of rheumatology,
J C Renier, and
C Bregeon, and
C Bonnette, and
M Boasson, and
M Bernat, and
M Basle, and
J Besson, and
C Wellinger, and
B Bourgeois, and
N Teisseire
January 2016,
Journal of Nippon Medical School = Nippon Ika Daigaku zasshi,
J C Renier, and
C Bregeon, and
C Bonnette, and
M Boasson, and
M Bernat, and
M Basle, and
J Besson, and
C Wellinger, and
B Bourgeois, and
N Teisseire
December 1981,
Recenti progressi in medicina,
