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A 73-year-old man who had suffered for many years from psoriasis was treated with systemic psoralen and longwave ultraviolet light. After 1 year he developed a preleukaemic condition characterized by a refractory anaemia, a slight thrombocytopenia and a normo- to hypercellular bone marrow with an excess of myeloblasts. Karyotyping revealed an abnormal chromosome (12p-) and agar cultures of bone marrow showed moderate growth with a high cluster/colony ratio. He died 1 year later of renal failure precipitated by an acute pancreatitis. Owing to the possible causal relationship we would like to advise increased attention to the haematopoietic system of patients treated with psoralen.
J Wagner, and
R Manthorpe, and
P Philip, and
F Frost
March 1985,
Clinical and experimental dermatology,
J Wagner, and
R Manthorpe, and
P Philip, and
F Frost
March 1979,
The British journal of dermatology,
J Wagner, and
R Manthorpe, and
P Philip, and
F Frost
September 1976,
Ugeskrift for laeger,
J Wagner, and
R Manthorpe, and
P Philip, and
F Frost
January 1977,
Acta dermato-venereologica,
J Wagner, and
R Manthorpe, and
P Philip, and
F Frost
January 1989,
The Journal of investigative dermatology,
J Wagner, and
R Manthorpe, and
P Philip, and
F Frost
January 1979,
Scandinavian journal of haematology,
J Wagner, and
R Manthorpe, and
P Philip, and
F Frost
January 1990,
Dermatologische Monatschrift,
J Wagner, and
R Manthorpe, and
P Philip, and
F Frost
April 1978,
Minerva medica,
J Wagner, and
R Manthorpe, and
P Philip, and
F Frost
July 1976,
Nederlands tijdschrift voor geneeskunde,
J Wagner, and
R Manthorpe, and
P Philip, and
F Frost
May 1999,
Journal of the American Academy of Dermatology,
