Biomaterial Database

Pharmacological and metabolic studies on amino acid benzocaine derivatives. 1981

Z Słojkowska, and K Misterek, and H Klimecka, and J Pachecka

Amino acid derivatives of benzocaine have shown local anesthetic properties similar to procaine in infiltration and block anesthesia tests, but were ineffective after topic application. Metabolic studies revealed the possibility of rapid hydrolysis of the derivatives to benzocaine by tissues and plasma hydrolyzing enzymes. Therefore they should be considered as prodrugs.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D006168	Guinea Pigs	A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.	Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D006868	Hydrolysis	The process of cleaving a chemical compound by the addition of a molecule of water.
D000779	Anesthetics, Local	Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.	Anesthetics, Conduction-Blocking,Conduction-Blocking Anesthetics,Local Anesthetic,Anesthetics, Topical,Anesthetic, Local,Anesthetics, Conduction Blocking,Conduction Blocking Anesthetics,Local Anesthetics,Topical Anesthetics
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001566	Benzocaine	A surface anesthetic that acts by preventing transmission of impulses along NERVE FIBERS and at NERVE ENDINGS.	Ethyl Aminobenzoate,4-Aminobenzoic Acid Ethyl Ester,Americaine,Anaesthesin,Anesthesin,Bensokain,Benzocaine Acetate,Benzocaine Formate,Benzocaine Hydrobromide,Benzocaine Hydrochloride,Benzocaine Methanesulfonate,Ethoform,Acetate, Benzocaine,Formate, Benzocaine,Hydrobromide, Benzocaine,Hydrochloride, Benzocaine,Methanesulfonate, Benzocaine