-transparent.png){kind=logo}
The most common abnormality of the platelets in 43 patients with a variety of myeloproliferative syndromes was impaired or absent aggregation when stimulated with collagen and adrenaline. Eight unselected cases studied in more detail showed a normal prostaglandin synthesis pathway as evidenced by normal aggregation with arachidonic acid and the production of normal amounts of malonyldialdehyde. Mixing experiments with aspirin-tested platelets showed correction of the abnormal adrenaline and collagen responses and confirmed that the nature of the defect was different from that induced by aspirin. Stimulation of "myeloproliferative" platelets with thrombin after blocking the prostaglandin pathway with aspirin resulted in reduced aggregation, indicating either a deficiency of the storage pool of adenine nucleotides in the platelets or an abnormality of a membrane receptor for thrombin.
K Phadke, and
S Dean, and
W R Pitney
January 2008,
Romanian journal of internal medicine = Revue roumaine de medecine interne,
K Phadke, and
S Dean, and
W R Pitney
January 1987,
Acta medica Scandinavica,
K Phadke, and
S Dean, and
W R Pitney
August 1995,
American journal of hematology,
K Phadke, and
S Dean, and
W R Pitney
January 1985,
Sangre,
K Phadke, and
S Dean, and
W R Pitney
May 2020,
La Revue de medecine interne,
K Phadke, and
S Dean, and
W R Pitney
January 1985,
Revista medica de Chile,
K Phadke, and
S Dean, and
W R Pitney
January 1987,
Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion,
K Phadke, and
S Dean, and
W R Pitney
April 1969,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
K Phadke, and
S Dean, and
W R Pitney
September 1982,
Thrombosis research,
K Phadke, and
S Dean, and
W R Pitney
November 2002,
Thrombosis research,
