Biomaterial Database

Dose-response effects of tropicamide HCl. 1981

S L Pollack, and J S Hunt, and K A Polse

Using double-masking procedures, the mydriatic and cycloplegic effects of 0.25, 0.5, 0.75, and 1.0% tropicamide were studied. All doses produced clinically useful mydriasis of at least 6-mm pupils. Using testing conditions of both normal (35 ft-c) and bright (150 ft-c) illumination, no mydriatic dose-response differences for the four concentrations were found. Cycloplegic effects were dose related. A single drop of either 0.75 or 1.0% tropicamide reduced the amplitude of accommodation to about 1.5 D, which is adequate for a cycloplegic refraction.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009184	Mydriatics	Agents that dilate the pupil. They may be either sympathomimetics or parasympatholytics.	Cycloplegic,Cycloplegics,Mydriatic,Mydriatic Effect,Mydriatic Effects,Effect, Mydriatic,Effects, Mydriatic
D011680	Pupil	The aperture in the iris through which light passes.	Pupils
D011725	Pyridines	Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.
D012029	Refraction, Ocular	Refraction of LIGHT effected by the media of the EYE.	Ocular Refraction,Ocular Refractions,Refractions, Ocular
D004305	Dose-Response Relationship, Drug	The relationship between the dose of an administered drug and the response of the organism to the drug.	Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004311	Double-Blind Method	A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.	Double-Masked Study,Double-Blind Study,Double-Masked Method,Double Blind Method,Double Blind Study,Double Masked Method,Double Masked Study,Double-Blind Methods,Double-Blind Studies,Double-Masked Methods,Double-Masked Studies,Method, Double-Blind,Method, Double-Masked,Methods, Double-Blind,Methods, Double-Masked,Studies, Double-Blind,Studies, Double-Masked,Study, Double-Blind,Study, Double-Masked
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D014331	Tropicamide	One of the MUSCARINIC ANTAGONISTS with pharmacologic action similar to ATROPINE and used mainly as an ophthalmic parasympatholytic or mydriatic.	Colircusi Tropicamida,Minims Tropicamide,Mydral,Mydriafair,Mydriaticum,Mydrum,N-Ethyl-N-(4-pyridylmethyl)tropamide,N-Ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)benzeneacetamide,Ocu-Tropic,Tropicacyl,Tropicamide Faure,Tropicamide Minims,Tropicamide Monofree,Tropicamide Monohydrochloride, (R)-Isomer,Tropicamide Monohydrochloride, (S)-Isomer,Tropicamide, (+-)-Isomer,Tropicamide, (R)-Isomer,Tropicamide, (S)-Isomer,Ocu Tropic,OcuTropic