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A very high glucose level in a diabetic was associated with an increased electronic mean corpuscular volume (MCV). The hematocrit was falsely high and the mean corpuscular hemoglobin concentration (MCHC) falsely low, while the mean corpuscular hemoglobin (MCH) was normal. Blood smears failed to corroborate the abdominal indices. Correct values could be obtained by predilution of the blood in isotomic medium and allowing 10 to 15 minutes for equilibration. It is suggested that glucose in the cell produces a hyperosmolar state which results in the rapid diffusion of water into the cells in the counter. The phenomenon is dependent on the concentration of glucose to which the red cell is exposed. It is temperature dependent and it is rapidly reversible.
E E Morse, and
G Kalache, and
W Germino, and
R Stockwell
October 1982,
American journal of clinical pathology,
E E Morse, and
G Kalache, and
W Germino, and
R Stockwell
February 1973,
The New England journal of medicine,
E E Morse, and
G Kalache, and
W Germino, and
R Stockwell
May 1982,
American journal of clinical pathology,
E E Morse, and
G Kalache, and
W Germino, and
R Stockwell
November 1973,
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E E Morse, and
G Kalache, and
W Germino, and
R Stockwell
August 2017,
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E E Morse, and
G Kalache, and
W Germino, and
R Stockwell
January 2018,
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E E Morse, and
G Kalache, and
W Germino, and
R Stockwell
January 1981,
JAMA,
E E Morse, and
G Kalache, and
W Germino, and
R Stockwell
August 2022,
Rheumatology (Oxford, England),
E E Morse, and
G Kalache, and
W Germino, and
R Stockwell
October 2014,
Archives of pathology & laboratory medicine,
E E Morse, and
G Kalache, and
W Germino, and
R Stockwell
December 2021,
Hematology (Amsterdam, Netherlands),
