Biomaterial Database

[Lipid peroxidation response in the liver and lungs of rats during prolonged cold adaptation]. 1981

N G Kolosova, and Iu P Shorin, and V Iu Kulikov

Prolonged cold adaptation in rats (+4-6 degrees C) is associated with phasic changes in lipid peroxidation. On the 7th day the quantity of liquid peroxidation products in the liver and lungs and the ability of liver lipids to take part in the ascorbate-dependent peroxidation were increased. Meanwhile the antioxidant activity of lipids was decreased. On the 30th and 49th days there was no difference in the data obtained. This evidenced the formation of adaptation which was characterized by an essential rise in the antioxidant activity of liver lipids, by their decreased ability to get oxidized in the presence of ascorbate and iron, by a reduced amount in the liver and lungs of the peroxidation products (control levels). Activation of lipid peroxidation is considered as a necessary prerequisite for the formation of the specialized adaptation mechanisms.

UI	MeSH Term	Description	Entries
D008054	Lipid Peroxides	Peroxides produced in the presence of a free radical by the oxidation of unsaturated fatty acids in the cell in the presence of molecular oxygen. The formation of lipid peroxides results in the destruction of the original lipid leading to the loss of integrity of the membranes. They therefore cause a variety of toxic effects in vivo and their formation is considered a pathological process in biological systems. Their formation can be inhibited by antioxidants, such as vitamin E, structural separation or low oxygen tension.	Fatty Acid Hydroperoxide,Lipid Peroxide,Lipoperoxide,Fatty Acid Hydroperoxides,Lipid Hydroperoxide,Lipoperoxides,Acid Hydroperoxide, Fatty,Acid Hydroperoxides, Fatty,Hydroperoxide, Fatty Acid,Hydroperoxide, Lipid,Hydroperoxides, Fatty Acid,Peroxide, Lipid,Peroxides, Lipid
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008168	Lung	Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.	Lungs
D008297	Male		Males
D003080	Cold Temperature	An absence of warmth or heat or a temperature notably below an accustomed norm.	Cold,Cold Temperatures,Temperature, Cold,Temperatures, Cold
D000064	Acclimatization	Adaptation to a new environment or to a change in the old.	Acclimation
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus