Biomaterial Database

Lung fluid and protein exchange in the acute sheep preparation. 1981

F L Minnear, and P S Barie, and A B Malik

We examined the effect of left atrial hypertension on lung fluid and protein exchange in acutely prepared anesthetized sheep. The results were compared with those reported by Erdmann jet al. (Circ. Res. 37:271-284, 1975) in chronically instrumented conscious sheep. Animals were anesthetized with halothane and efferent duct of the caudal mediastinal node was cannulated. Pulmonary microvascular pressure (Pmv) was elevated by raising left atrial pressure with a left atrial balloon. For every elevation in Pmv of 1 cmH2O pulmonary lymph flow (Qlym) increased by 0.5 ml/h. Increasing the Pmv resulted in a linear decrease (p less than 0.05) in the ratio of lymph to plasma protein concentration as a result of a significant reduction in lymph protein concentration. Transvascular clearance of lymph proteins increased by 39% with a doubling of Qlym. The steady-state changes in pulmonary fluid and protein exchange induced by an increase in Pmv in acutely prepared anesthetized sheep were the same as those observed by Erdmann et al. in chronically instrumented unanesthetized sheep, indicating that the acute preparation is equally reactive to increase in Pmv and that the lung endothelial permeability is not increased.

UI	MeSH Term	Description	Entries
D006973	Hypertension	Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.	Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures
D008168	Lung	Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.	Lungs
D008196	Lymph	The interstitial fluid that is in the LYMPHATIC SYSTEM.	Lymphs
D001798	Blood Proteins	Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.	Blood Protein,Plasma Protein,Plasma Proteins,Serum Protein,Serum Proteins,Protein, Blood,Protein, Plasma,Protein, Serum,Proteins, Blood,Proteins, Plasma,Proteins, Serum
D002199	Capillary Permeability	The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.	Microvascular Permeability,Permeability, Capillary,Permeability, Microvascular,Vascular Permeability,Capillary Permeabilities,Microvascular Permeabilities,Permeabilities, Capillary,Permeabilities, Microvascular,Permeabilities, Vascular,Permeability, Vascular,Vascular Permeabilities
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012756	Sheep	Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.	Ovis,Sheep, Dall,Dall Sheep,Ovis dalli