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Eleven patients with intrinsic asthma and aspirin sensitivity were challenged with intravenous hydrocortisone sodium succinate (Solu-Cortef; the Upjohn Co., Kalamazoo, Mich.). Three patients showed definite evidence of bronchospasm, which was easily reversed by subcutaneous administration of epinephrine. Evidence is presented which suggests that this reaction was not caused by other constituents of the preparation but rather was caused by Solu-Cortef alone. No atopy was demonstrated in the group as a whole, and the reaction observed was probably nonallergic in nature. We suggest the replacement of intravenous hydrocortisone sodium succinate with dexamethasone in the treatment of such a population.
B M Dajani, and
N A Sliman, and
K S Shubair, and
Y S Hamzeh
August 1993,
Nihon Kyobu Shikkan Gakkai zasshi,
B M Dajani, and
N A Sliman, and
K S Shubair, and
Y S Hamzeh
August 1975,
Scandinavian journal of haematology,
B M Dajani, and
N A Sliman, and
K S Shubair, and
Y S Hamzeh
June 1990,
Nihon Kyobu Shikkan Gakkai zasshi,
B M Dajani, and
N A Sliman, and
K S Shubair, and
Y S Hamzeh
October 1995,
The Journal of allergy and clinical immunology,
B M Dajani, and
N A Sliman, and
K S Shubair, and
Y S Hamzeh
June 1991,
The Medical journal of Australia,
B M Dajani, and
N A Sliman, and
K S Shubair, and
Y S Hamzeh
January 1983,
Critical care nurse,
B M Dajani, and
N A Sliman, and
K S Shubair, and
Y S Hamzeh
December 1984,
The American review of respiratory disease,
B M Dajani, and
N A Sliman, and
K S Shubair, and
Y S Hamzeh
July 1976,
Clinical pharmacology and therapeutics,
B M Dajani, and
N A Sliman, and
K S Shubair, and
Y S Hamzeh
March 1985,
Nihon Kyobu Shikkan Gakkai zasshi,
B M Dajani, and
N A Sliman, and
K S Shubair, and
Y S Hamzeh
January 1986,
The Journal of asthma : official journal of the Association for the Care of Asthma,
