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An enzyme-linked immunoassay was used to detect antibodies to the cell wall peptidoglycan of Staphylococcus aureus in human sera. All 170 sera from donors and patients with staphylococcal and nonstaphylococcal infections contained IgG antibodies to peptidoglycan; antibody levels varied with age, and transplacental transfer occurred. IgM antibodies to peptidoglycan were not found in donors and were present in only one patient with serious staphylococcal infection. Significantly elevated levels of IgG antibodies to peptidoglycan were observed in 20 (80%) of 25 patients with deep tissue infection with S. aureus but in only two (9%) of 22 patients with superficial staphylococcal infection. An increase in levels of antibodies to peptidoglycan generally coincided with an increase in level of IgG antibodies to teichoic acid. No cross-reactivity between peptidoglycan and teichoic acid was observed. Thus, staphylococcal peptidoglycan is immunogenic in humans, and testing for IgG antibodies to peptidoglycan may be useful in the diagnosis and follow-up of serious staphylococcal infections.
H A Verbrugh, and
R Peters, and
M Rozenberg-Arska, and
P K Peterson, and
J Verhoef
January 1983,
Scandinavian journal of infectious diseases. Supplementum,
H A Verbrugh, and
R Peters, and
M Rozenberg-Arska, and
P K Peterson, and
J Verhoef
December 1983,
Acta pathologica, microbiologica, et immunologica Scandinavica. Section B, Microbiology,
H A Verbrugh, and
R Peters, and
M Rozenberg-Arska, and
P K Peterson, and
J Verhoef
October 1984,
Acta pathologica, microbiologica, et immunologica Scandinavica. Section B, Microbiology,
H A Verbrugh, and
R Peters, and
M Rozenberg-Arska, and
P K Peterson, and
J Verhoef
January 1985,
Scandinavian journal of infectious diseases,
H A Verbrugh, and
R Peters, and
M Rozenberg-Arska, and
P K Peterson, and
J Verhoef
April 1979,
The New England journal of medicine,
H A Verbrugh, and
R Peters, and
M Rozenberg-Arska, and
P K Peterson, and
J Verhoef
October 1996,
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society,
H A Verbrugh, and
R Peters, and
M Rozenberg-Arska, and
P K Peterson, and
J Verhoef
May 1976,
Annals of internal medicine,
H A Verbrugh, and
R Peters, and
M Rozenberg-Arska, and
P K Peterson, and
J Verhoef
December 1990,
FEMS microbiology immunology,
H A Verbrugh, and
R Peters, and
M Rozenberg-Arska, and
P K Peterson, and
J Verhoef
January 1993,
Likars'ka sprava,
H A Verbrugh, and
R Peters, and
M Rozenberg-Arska, and
P K Peterson, and
J Verhoef
April 2006,
Journal of bacteriology,
