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A biocontainment facility was built for studies in which the chemical carcinogen N-methyl-N-nitrosourea (MNU) was instilled intrarectally in guinea pigs. The system operated by constant flow of uncontaminated air into carcinogen-contaminated animal isolation chambers and filtration through a high-efficiency particulate air (HEPA) filter prior to release into the environment. The facility was tested for efficiency of carcinogen containment by substituting for the MNU a similar concentration of a fluorescent tracer, sodium fluorescein, under standard operating procedures for carcinogen administration to guinea pigs. Wipe samples from the floor, isolation chambers, animal handlers and clothing, and intake and exhaust air samples were analyzed for fluorescein before and after intrarectal instillation of the tracer. The recovery of very low concentrations of total and respirable suspended fluorescein from sampling points within the facility and the absence of detectable fluorescein in the air downstream from the HEPA filter indicated that the facility provided adequate protection against contamination of personnel or the environment.
G L Cockerell, and
J E Gilmartin, and
W F Albern, and
A M Losikoff, and
E B Sansone
January 1981,
Neoplasma,
G L Cockerell, and
J E Gilmartin, and
W F Albern, and
A M Losikoff, and
E B Sansone
July 1993,
Journal of industrial microbiology,
G L Cockerell, and
J E Gilmartin, and
W F Albern, and
A M Losikoff, and
E B Sansone
June 2015,
The Journal of nursing administration,
G L Cockerell, and
J E Gilmartin, and
W F Albern, and
A M Losikoff, and
E B Sansone
December 1999,
Russian journal of immunology : RJI : official journal of Russian Society of Immunology,
G L Cockerell, and
J E Gilmartin, and
W F Albern, and
A M Losikoff, and
E B Sansone
April 1976,
Science (New York, N.Y.),
G L Cockerell, and
J E Gilmartin, and
W F Albern, and
A M Losikoff, and
E B Sansone
January 1982,
Chemico-biological interactions,
G L Cockerell, and
J E Gilmartin, and
W F Albern, and
A M Losikoff, and
E B Sansone
December 2018,
Genes,
G L Cockerell, and
J E Gilmartin, and
W F Albern, and
A M Losikoff, and
E B Sansone
January 1985,
Archiv fur Geschwulstforschung,
G L Cockerell, and
J E Gilmartin, and
W F Albern, and
A M Losikoff, and
E B Sansone
August 1978,
Mutation research,
G L Cockerell, and
J E Gilmartin, and
W F Albern, and
A M Losikoff, and
E B Sansone
October 1950,
A.M.A. archives of industrial hygiene and occupational medicine,
