Biomaterial Database

Reduced vaccinal protection of turkey herpesvirus against field strains of Marek's disease herpesvirus. 1981

C S Eidson, and M N Ellis, and S H Kleven

Four isolates of Marek's disease herpesvirus (MDV) were obtained from 21-week-old broiler breeders with lesions and mortality from Marek's disease (MD). They had been properly vaccinated with turkey herpesvirus (HVT). The isolates were designated Ala-7, 8, 9, and 10. These 4 MDV strains were compared with the GA isolate of MDV in chickens vaccinated with graded doses of HVT. Challenge with the MDV strains was also with graded doses. All 5 isolates of MDV were similar in virulence. However, protection afforded against MD lesions by HVT was significantly lower in the Ala-7, 8, and 9 isolates than with the Ala-10 or GA isolates. The Ala-7, 8 and 9 isolates of MDV induced small-cell plaques in chick embryo fibroblasts, the Ala-10 isolate induced both large and small cell per plaque types, and the GA isolate produced predominantly small cell plaques with a few plaques of the large cell type.

UI	MeSH Term	Description	Entries
D008380	Marek Disease	A transmissible viral disease of birds caused by avian herpesvirus 2 (HERPESVIRUS 2, GALLID) and other MARDIVIRUS. There is lymphoid cell infiltration or lymphomatous tumor formation in the peripheral nerves and gonads, but may also involve visceral organs, skin, muscle, and the eye.	Fowl Paralysis,Marek's Disease,Fowl Paralyses,Mareks Disease,Paralyses, Fowl,Paralysis, Fowl
D011200	Poultry	Domesticated birds raised for food. It typically includes CHICKENS; TURKEYS, DUCKS; GEESE; and others.	Fowls, Domestic,Domestic Fowl,Domestic Fowls,Fowl, Domestic,Poultries
D011201	Poultry Diseases	Diseases of birds which are raised as a source of meat or eggs for human consumption and are usually found in barnyards, hatcheries, etc. The concept is differentiated from BIRD DISEASES which is for diseases of birds not considered poultry and usually found in zoos, parks, and the wild.	Disease, Poultry,Diseases, Poultry,Poultry Disease
D002645	Chickens	Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.	Gallus gallus,Gallus domesticus,Gallus gallus domesticus,Chicken
D006564	Herpesviridae	A family of enveloped, linear, double-stranded DNA viruses infecting a wide variety of animals. Subfamilies, based on biological characteristics, include: ALPHAHERPESVIRINAE; BETAHERPESVIRINAE; and GAMMAHERPESVIRINAE.	Mouse Thymic Virus,Murid herpesvirus 3,Thymic Group Viruses,Herpesviruses,Mouse Thymic Viruses,Thymic Virus, Mouse,Thymic Viruses, Mouse
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014422	Turkeys	Large woodland game BIRDS in the subfamily Meleagridinae, family Phasianidae, order GALLIFORMES. Formerly they were considered a distinct family, Melegrididae.	Meleagridinae,Meleagrididae
D014765	Viral Vaccines	Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.	Viral Vaccine,Vaccine, Viral,Vaccines, Viral