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Two cases of duodenal villous adenoma are reported, bringing the total reported in the world literature to 51. The tumors are of importance despite their rarity because of the frequency of focal or occult malignant changes in the tumors, the nonspecific symptoms and radiographic findings and the potential surgical complications. Therefore, atypical lesions of the duodenum should be investigated endoscopically and all duodenal villous tumors should be surgically resected. Local excision is usually adequate treatment even when microinvasive cancer or carcinoma in situ are present.
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