Biomaterial Database

Variation in canine exocrine pancreatic secretory activity during the interdigestive state. 1981

Z Itoh, and I Takahashi, and M Nakaya, and T Suzuki

Interdigestive changes in pancreatic volume flow, gastric motor activity, and intraduodenal pH were monitored automatically in eight dogs. As a result, two different periods of pancreatic secretion were found to occur alternately during the interdigestive state: one a secretory period (2.2 +/- 0.32 ml/10 min with high protein and low bicarbonate concentration) and the other a nonsecretory period. The secretory period corresponded to the interdigestive phase II and III contraction period in the stomach, and the nonsecretory period coincided with the motor quiescent period in the stomach. However, another secretory period was identified during the interdigestive state; it occurred when the intraduodenal pH went below 7.0, and no typical interdigestive contractions were observed in the stomach. The secretory rate was 3.7 +/- 0.33 ml/10 min and was low in protein and high in bicarbonate concentration. The present study demonstrates that basal pancreatic secretory activity is never uniform but fluctuates with motor events in the stomach. However, its control mechanism remains unknown at present.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D010179	Pancreas	A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
D010185	Pancreatic Fistula	Abnormal passage communicating with the PANCREAS.	Fistula, Pancreatic,Fistulas, Pancreatic,Pancreatic Fistulas
D011506	Proteins	Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.	Gene Products, Protein,Gene Proteins,Protein,Protein Gene Products,Proteins, Gene
D004063	Digestion	The process of breakdown of food for metabolism and use by the body.
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D004386	Duodenum	The shortest and widest portion of the SMALL INTESTINE adjacent to the PYLORUS of the STOMACH. It is named for having the length equal to about the width of 12 fingers.	Duodenums
D005260	Female		Females
D006863	Hydrogen-Ion Concentration	The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH	pH,Concentration, Hydrogen-Ion,Concentrations, Hydrogen-Ion,Hydrogen Ion Concentration,Hydrogen-Ion Concentrations
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia