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Six slow acetylators (SAs) and six rapid acetylators (RAs), as determined by sulfamethazine (SMZ) phenotyping, were each given a 2-mg oral dose of clonazepam. Ninety-six-hour urine collections from these subjects were analyzed for clonazepam, 7-amino clonazepam (7-AM, clonazepam nitroreduced metabolite), and 7-acetamido clonazepam (7-ACT, N-acetylated 7-AM). The SA group excreted more 7-AM and less 7-ACT than the RA group; mean (+/- Sd) recovered as 7-AM was 22.7 +/- 5.0% for the SA group and 13.6 +/- 4.1% for the RA group and mean (+/- SD) recovered as 7-ACT was 1.5 +/- 0.4% for the SA group and 3.9 +/- 1.8% for the RA group. Both differences were substantial (p less than 0.02 by unpaired t test) and indicate that the rate of acetylation of 7-AM to 7-ACT in the biotransformation of clonazepam is determined by the acetylator phenotype.
M E Miller, and
W A Garland, and
B H Min, and
B T Ludwick, and
R H Ballard, and
R H Levy
April 1990,
International journal of clinical pharmacology, therapy, and toxicology,
M E Miller, and
W A Garland, and
B H Min, and
B T Ludwick, and
R H Ballard, and
R H Levy
January 1974,
Canadian journal of public health = Revue canadienne de sante publique,
M E Miller, and
W A Garland, and
B H Min, and
B T Ludwick, and
R H Ballard, and
R H Levy
January 1983,
Biopharmaceutics & drug disposition,
M E Miller, and
W A Garland, and
B H Min, and
B T Ludwick, and
R H Ballard, and
R H Levy
January 2002,
Acta poloniae pharmaceutica,
M E Miller, and
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B H Min, and
B T Ludwick, and
R H Ballard, and
R H Levy
January 2002,
Pneumonologia i alergologia polska,
M E Miller, and
W A Garland, and
B H Min, and
B T Ludwick, and
R H Ballard, and
R H Levy
November 1967,
Experientia,
M E Miller, and
W A Garland, and
B H Min, and
B T Ludwick, and
R H Ballard, and
R H Levy
December 1980,
Clinical pharmacology and therapeutics,
M E Miller, and
W A Garland, and
B H Min, and
B T Ludwick, and
R H Ballard, and
R H Levy
January 1980,
Casopis lekaru ceskych,
M E Miller, and
W A Garland, and
B H Min, and
B T Ludwick, and
R H Ballard, and
R H Levy
January 1980,
British journal of clinical pharmacology,
M E Miller, and
W A Garland, and
B H Min, and
B T Ludwick, and
R H Ballard, and
R H Levy
March 1976,
Annals of tropical medicine and parasitology,
