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This historical development, biosynthesis, analysis, interpretation, and utilization of glycosylated hemoglobin determinations (HbA1 or HbA1c alone) are presented. The relationship between glycosylated hemoglobin determinations and assessment of diabetic control is discussed. HbA1 and HbA1c levels are elevated approximately twofold in diabetic patients. A correlation exists between abnormal fluctuations in blood glucose levels and HbA1 concentrations. The results of glycosylated hemoglobin determinations are not influenced by recent meals, physical activity, emotional stress, or inherited abnormalities. Although glycosylated hemoglobin determinations are subject to fewer variables than blood and urine glucose assessments, the clinician must be aware of the indications and limitations for their use. These indications and limitations are discussed.
M S Torre, and
D H Schofield, and
R A Mangione
January 1986,
Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina),
M S Torre, and
D H Schofield, and
R A Mangione
January 1979,
La Nouvelle presse medicale,
M S Torre, and
D H Schofield, and
R A Mangione
June 1980,
Clinical chemistry,
M S Torre, and
D H Schofield, and
R A Mangione
September 1982,
The Nurse practitioner,
M S Torre, and
D H Schofield, and
R A Mangione
January 1980,
Texas reports on biology and medicine,
M S Torre, and
D H Schofield, and
R A Mangione
May 1983,
The Journal of clinical investigation,
M S Torre, and
D H Schofield, and
R A Mangione
January 1987,
Medicinski pregled,
M S Torre, and
D H Schofield, and
R A Mangione
January 1980,
Annals of the Academy of Medicine, Singapore,
M S Torre, and
D H Schofield, and
R A Mangione
August 1983,
Singapore medical journal,
M S Torre, and
D H Schofield, and
R A Mangione
January 1987,
Clinical physiology and biochemistry,
