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A competitive solid-phase radioimmunoassay (RIA) for antibody to hepatitis B core antigen (anti-HBc) was set up using purified hepatitis B core antigen and 125I-labeled anti-HBc. RIA was compared with counter-immunoelectrophoresis (CIEP) for anti-HBc by examining a panel of quality control sera, clinical specimens screened for evidence of hepatitis B virus infection and sera collected during a VD clinic survey. RIA for anti-HBc was found to be more sensitive and more specific than CIEP. It detected anti-HBc in all HBsAg-positive and in most anti-HBs-positive patients. CIEP for anti-HBc was also positive in almost all HBsAg-positive patients but was frequently negative in anti-HBs-positive patients. Non-specific reactions occurred in both tests but by RIA they could be more easily distinguished from true positives.
B J Cohen, and
R A Hewish, and
P P Mortimer
September 1978,
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B J Cohen, and
R A Hewish, and
P P Mortimer
January 1972,
Canadian journal of public health = Revue canadienne de sante publique,
B J Cohen, and
R A Hewish, and
P P Mortimer
September 1978,
Vox sanguinis,
B J Cohen, and
R A Hewish, and
P P Mortimer
January 1980,
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B J Cohen, and
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P P Mortimer
November 1979,
Radioisotopes,
B J Cohen, and
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P P Mortimer
February 1982,
Clinical chemistry,
B J Cohen, and
R A Hewish, and
P P Mortimer
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Military medicine,
B J Cohen, and
R A Hewish, and
P P Mortimer
January 1980,
Voprosy virusologii,
B J Cohen, and
R A Hewish, and
P P Mortimer
October 1995,
Nihon rinsho. Japanese journal of clinical medicine,
B J Cohen, and
R A Hewish, and
P P Mortimer
December 1977,
Vox sanguinis,
