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The effect of ethylene thiourea on microsomal liver enzymes of rat has been studied by measuring hexobarbital sleeping time and determining aminopyrine-N-demethylase and aniline-hydroxilase activities. Single oral doses of 50, 100 and 200 mg/kg body mass caused significant prolongation of the sleeping time in males. The same effect was caused by 200 mg/kg in females. When ethylene thiourea was administered in the diet at a level of 200 ppm sleeping time in males increased with duration of administration. The duration of narcosis of females increased up to the third week and remained almost constand over the following feeding period. The aminopyrine-N-demethylase and aniline-hydroxylase activities in the liver of male rats were inhibited by single doses of 20 mg/kg or more. Inhibition and subsequent enzyme change depended on dosage.
R Plass, and
H J Lewerenz
March 1972,
Chemico-biological interactions,
R Plass, and
H J Lewerenz
January 1985,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
R Plass, and
H J Lewerenz
August 1971,
The Biochemical journal,
R Plass, and
H J Lewerenz
September 1962,
The Journal of pharmacology and experimental therapeutics,
R Plass, and
H J Lewerenz
February 1973,
Food and cosmetics toxicology,
R Plass, and
H J Lewerenz
May 1970,
Toxicology and applied pharmacology,
R Plass, and
H J Lewerenz
January 1970,
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R Plass, and
H J Lewerenz
January 1971,
Klinische Wochenschrift,
R Plass, and
H J Lewerenz
September 1975,
Toxicology and applied pharmacology,
R Plass, and
H J Lewerenz
August 1974,
Biochemical pharmacology,
