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A mathematical model of glycolysis in human erythrocytes for the interaction between the Embden-Meyerhof and the pentose phosphate pathways has been developed. The characteristic surfaces, i. e. interdependencies between the rates of metabolite flows in both pathways and ATP and NADPH concentrations have been calculated. The model obtained is well correlated with the experimental data on glycolysis characteristic at low rates of the pentose phosphate pathway reactions. The model suggests that NADPH and GSH concentrations should be stabilized. At ATP and NADPH concentrations close to the physiological ones the Embden-Meyerhof and pentose phosphate pathways function practically independently. When the NADPH concentration is decreased below 80% of the physiological value, the system ceases to stabilize the ATP concentration. In its turn, a decrease of ATP concentration results in a corresponding decrease of the maximal rate of the pentose phosphate pathway.
F I Ataullakhanov, and
V N Buravtsev, and
A M Zhabotinskiĩ, and
S B Norina, and
A V Pichugin
January 1965,
Acta biologica et medica Germanica,
F I Ataullakhanov, and
V N Buravtsev, and
A M Zhabotinskiĩ, and
S B Norina, and
A V Pichugin
May 1987,
Acta endocrinologica,
F I Ataullakhanov, and
V N Buravtsev, and
A M Zhabotinskiĩ, and
S B Norina, and
A V Pichugin
December 1968,
Minerva pediatrica,
F I Ataullakhanov, and
V N Buravtsev, and
A M Zhabotinskiĩ, and
S B Norina, and
A V Pichugin
May 1971,
Journal of bacteriology,
F I Ataullakhanov, and
V N Buravtsev, and
A M Zhabotinskiĩ, and
S B Norina, and
A V Pichugin
July 2003,
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
F I Ataullakhanov, and
V N Buravtsev, and
A M Zhabotinskiĩ, and
S B Norina, and
A V Pichugin
September 1971,
Journal of bacteriology,
F I Ataullakhanov, and
V N Buravtsev, and
A M Zhabotinskiĩ, and
S B Norina, and
A V Pichugin
January 1990,
Comparative biochemistry and physiology. B, Comparative biochemistry,
F I Ataullakhanov, and
V N Buravtsev, and
A M Zhabotinskiĩ, and
S B Norina, and
A V Pichugin
November 1989,
European journal of haematology,
F I Ataullakhanov, and
V N Buravtsev, and
A M Zhabotinskiĩ, and
S B Norina, and
A V Pichugin
July 2001,
American journal of veterinary research,
F I Ataullakhanov, and
V N Buravtsev, and
A M Zhabotinskiĩ, and
S B Norina, and
A V Pichugin
October 1976,
The Journal of clinical investigation,
