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Diethylcarbamazine (DEC), 0.5 mg/kg, was taken orally by six patients being treated for onchocerciasis. Blood samples were taken at timed intervals for 48 hr and urine and feces collected for 4 days. Plasma and urinary concentrations of DEC and DEC N-oxide were measured by gas-liquid chromatography. DEC appeared to be rapidly absorbed, with a peak plasma concentration of 150 to 250 ng/ml reached in 2 to 3 hr. There was a secondary rise in plasma DEC concentration at 5 to 6 hr in all patients. In contrast to the way the drug is eliminated in rats, in man it was by both renal and extrarenal routes, with small amounts (+/- 10%) being excreted as an N-oxide metabolite. DEC kinetics were also investigated in five normal subjects and the result were much the same. Clinical implications are discussed.
G Edwards, and
K Awadzi, and
A M Breckenridge, and
H M Gilles, and
M L Orme, and
S A Ward
November 1977,
The British journal of dermatology,
G Edwards, and
K Awadzi, and
A M Breckenridge, and
H M Gilles, and
M L Orme, and
S A Ward
October 1992,
British journal of clinical pharmacology,
G Edwards, and
K Awadzi, and
A M Breckenridge, and
H M Gilles, and
M L Orme, and
S A Ward
December 1951,
Revista. Asociacion Medica Mexicana,
G Edwards, and
K Awadzi, and
A M Breckenridge, and
H M Gilles, and
M L Orme, and
S A Ward
May 1980,
Lancet (London, England),
G Edwards, and
K Awadzi, and
A M Breckenridge, and
H M Gilles, and
M L Orme, and
S A Ward
January 1972,
Israel journal of medical sciences,
G Edwards, and
K Awadzi, and
A M Breckenridge, and
H M Gilles, and
M L Orme, and
S A Ward
January 1973,
Transactions of the Royal Society of Tropical Medicine and Hygiene,
G Edwards, and
K Awadzi, and
A M Breckenridge, and
H M Gilles, and
M L Orme, and
S A Ward
March 1976,
The American journal of tropical medicine and hygiene,
G Edwards, and
K Awadzi, and
A M Breckenridge, and
H M Gilles, and
M L Orme, and
S A Ward
February 1980,
Lancet (London, England),
G Edwards, and
K Awadzi, and
A M Breckenridge, and
H M Gilles, and
M L Orme, and
S A Ward
January 1969,
Transactions of the Royal Society of Tropical Medicine and Hygiene,
G Edwards, and
K Awadzi, and
A M Breckenridge, and
H M Gilles, and
M L Orme, and
S A Ward
December 1980,
Lancet (London, England),
