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[Pharmacokinetic characteristics of 14C-peritol based on data on its distribution in rat tissue]. 1981

A N Dedenkov, and G K Korolev, and V V Kurchatova, and V A Romantsova

Peritol (cyproheptadine) is chemically 1-methyl-4-(5-dibenzo-cyclohepta-trenilidin)-piperidine hydrochloride. It has a pronounced antihistamine and antiserotonin action. When injected intravenously to rats 14C-peritol is rapidly excreted from blood (T 1/2 = 2 h). The concentration of 14C-peritol as judged from the absorption ratio (AR), varies within the first 15 minutes. The magnitude of the AR ranged within 0.44 (muscles) to 17.1 (kidneys) on intravenous injection, and within 0.1 (skin) to 5.5 (liver) when administered into the stomach. Excretion of the label from the body (intravenous administration) occurred from T 1/2 = 44 h, and from T 1/2 = 40 h (intragastric administration). The total amount of radioactivity resorbed from the gastrointestinal tract was equal to 46.3% at the height of accumulation by organs and tissues (one hour after administration). Radiochromatography made it possible to disclose that 14C-peritol was retained in the rat body for 6 hours whereupon underwent metabolism.

UI MeSH Term Description Entries
D007275 Injections, Intravenous Injections made into a vein for therapeutic or experimental purposes. Intravenous Injections,Injection, Intravenous,Intravenous Injection
D003533 Cyproheptadine A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc. Antergan,Dihexazin,Periactin,Peritol,Viternum
D000042 Absorption The physical or physiological processes by which substances, tissue, cells, etc. take up or take in other substances or energy.
D000284 Administration, Oral The giving of drugs, chemicals, or other substances by mouth. Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor
D014018 Tissue Distribution Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios. Distribution, Tissue,Distributions, Tissue,Tissue Distributions
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

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