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Simultaneous determinations of unconjugated estradiol (E2), estriol (E3) and 15 alpha-hydroxyestriol (E4) levels in maternal serum were studied serially to ascertain the significance of these estrogens in the feto-placental unit. The samples of serum were collected serially from 25 normal and 44 abnormal pregnancies. In normal pregnancy, these estrogen levels increased throughout pregnancy, especially E3 and E4 nearing the term. In 15 cases of IUGR pregnancy (including 4 cases of perinatal death), E2 levels were mostly low (less than M -- S.D.), E3 was within normal limits (M +/- S.D.) or low, and E4 was either high (greater than M + S.D.) or relatively low, and normal. In 9 cases of twin pregnancy, most E2 levels were within normal limits, while E3 and E4 were remarkedly high. The results signified that E2 indicated placental function, that E3 indicated placental and fetal function, and that E4 indicated fetal function.
K Muraguchi, and
K Takahashi, and
M Suzuki, and
N Ikeno
January 1981,
Nihon Sanka Fujinka Gakkai zasshi,
K Muraguchi, and
K Takahashi, and
M Suzuki, and
N Ikeno
October 1985,
American journal of perinatology,
K Muraguchi, and
K Takahashi, and
M Suzuki, and
N Ikeno
January 1979,
Horumon to rinsho. Clinical endocrinology,
K Muraguchi, and
K Takahashi, and
M Suzuki, and
N Ikeno
July 1981,
Nihon Naibunpi Gakkai zasshi,
K Muraguchi, and
K Takahashi, and
M Suzuki, and
N Ikeno
June 1979,
Acta Europaea fertilitatis,
K Muraguchi, and
K Takahashi, and
M Suzuki, and
N Ikeno
July 1978,
Clinical chemistry,
K Muraguchi, and
K Takahashi, and
M Suzuki, and
N Ikeno
September 1981,
Obstetrics and gynecology,
K Muraguchi, and
K Takahashi, and
M Suzuki, and
N Ikeno
January 1985,
Acta obstetricia et gynecologica Scandinavica,
K Muraguchi, and
K Takahashi, and
M Suzuki, and
N Ikeno
August 1983,
Steroids,
K Muraguchi, and
K Takahashi, and
M Suzuki, and
N Ikeno
August 1981,
Nihon Sanka Fujinka Gakkai zasshi,
