Research investigating the relationship between marijuana use and alienation is characterized by conflicting findings and a relative lack of multivariate designs. although a number of potential explanations for this lack of consensus are assessed, the primary focus of this study is on the type of analysis employed. Using bivariate analysis, significant positive associations were found between marijuana use and anomia, political alienation, and social isolation. However, when these same relationships were investigated in a multivariate design, controlling for other relevant factors, they failed to remain significant. These results indicate that there is no direct relationship between marijuana use and alienation. furthermore, the results question studies that have not taken into consideration relevant control variables in their analyses.