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The effect of buprenorphine on the cardiovascular system was examined in 11 patients during the period of reduced cardiac reserve after open-heart surgery. Within 10 minutes of giving the full analgesic dose (5 microgram/kg) intravenously the mean heart rate had fallen significantly by six beats/min. Although in two patients the mean arterial pressure fell by 24 mm Hg, there was no overall change in mean arterial pressure, cardiac output, or peripheral resistance. In a further six patients buprenorphine was used successfully as the sole analgesic after open-heart surgery. Buprenorphine appears to be safer than morphine for use in patients with reduced cardiac reserve and is of similar analgesic efficacy.
F L Rosenfeldt, and
B Houston, and
D Thompson, and
N Naqui, and
A D Malcolm, and
B T Williams, and
D J Coltart
February 1979,
British medical journal,
F L Rosenfeldt, and
B Houston, and
D Thompson, and
N Naqui, and
A D Malcolm, and
B T Williams, and
D J Coltart
November 1979,
British heart journal,
F L Rosenfeldt, and
B Houston, and
D Thompson, and
N Naqui, and
A D Malcolm, and
B T Williams, and
D J Coltart
August 1974,
British medical journal,
F L Rosenfeldt, and
B Houston, and
D Thompson, and
N Naqui, and
A D Malcolm, and
B T Williams, and
D J Coltart
August 2023,
Acta anaesthesiologica Scandinavica,
F L Rosenfeldt, and
B Houston, and
D Thompson, and
N Naqui, and
A D Malcolm, and
B T Williams, and
D J Coltart
December 1980,
British journal of anaesthesia,
F L Rosenfeldt, and
B Houston, and
D Thompson, and
N Naqui, and
A D Malcolm, and
B T Williams, and
D J Coltart
January 1983,
British journal of anaesthesia,
F L Rosenfeldt, and
B Houston, and
D Thompson, and
N Naqui, and
A D Malcolm, and
B T Williams, and
D J Coltart
July 1977,
British heart journal,
F L Rosenfeldt, and
B Houston, and
D Thompson, and
N Naqui, and
A D Malcolm, and
B T Williams, and
D J Coltart
January 1994,
British journal of anaesthesia,
F L Rosenfeldt, and
B Houston, and
D Thompson, and
N Naqui, and
A D Malcolm, and
B T Williams, and
D J Coltart
January 1980,
Anesthesie, analgesie, reanimation,
F L Rosenfeldt, and
B Houston, and
D Thompson, and
N Naqui, and
A D Malcolm, and
B T Williams, and
D J Coltart
October 1980,
Anaesthesia,
