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The ability of interferon-treated macrophages to kill or inhibit the growth of tumor cells is markedly influenced by the local environment. The macrophage cytotoxic effector system is regulated by serum and other environmental factors that suppress tumor killing. Prostaglandins E1 and E2, but not F2alpha reversibly inhibited the tumoricidal state of interferon-treated macrophages. Hydrocortisone was similarly active at suppressing macrophage function. Such nonimmunologically derived factors could prevent the final triggering step for macrophage-mediated tumor killing in the local environment of the tumor and may be important in the pathogenesis of progressive tumor growth.
R M Schultz, and
N A Pavlidis, and
W A Stylos, and
M A Chirigos
May 1974,
The Journal of experimental medicine,
R M Schultz, and
N A Pavlidis, and
W A Stylos, and
M A Chirigos
February 1986,
Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology,
R M Schultz, and
N A Pavlidis, and
W A Stylos, and
M A Chirigos
October 1987,
Biulleten' eksperimental'noi biologii i meditsiny,
R M Schultz, and
N A Pavlidis, and
W A Stylos, and
M A Chirigos
August 1973,
Experimental cell research,
R M Schultz, and
N A Pavlidis, and
W A Stylos, and
M A Chirigos
October 1993,
The Journal of surgical research,
R M Schultz, and
N A Pavlidis, and
W A Stylos, and
M A Chirigos
January 1986,
Microbiology and immunology,
R M Schultz, and
N A Pavlidis, and
W A Stylos, and
M A Chirigos
May 1991,
International immunology,
R M Schultz, and
N A Pavlidis, and
W A Stylos, and
M A Chirigos
January 1989,
Giornale di batteriologia, virologia ed immunologia,
R M Schultz, and
N A Pavlidis, and
W A Stylos, and
M A Chirigos
January 1986,
Cancer immunology, immunotherapy : CII,
R M Schultz, and
N A Pavlidis, and
W A Stylos, and
M A Chirigos
December 1985,
Journal of cellular physiology,
