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Metabolism of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone(M73101), A New anti-inflammatory agent. I. Identification of the metabolites in rabbit and their pharmacological studies. 1978

T Hayashi, and M Sato, and M Ohki, and T Kishikawa

UI MeSH Term Description Entries
D007928 Lethal Dose 50 The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population. LD50,Dose 50, Lethal
D009025 Morpholines Tetrahydro-1,4-Oxazines,Tetrahydro 1,4 Oxazines
D011724 Pyridazines Six-membered rings with two adjacent nitrogen atoms also called 1,2-diazine.
D011817 Rabbits A burrowing plant-eating mammal with hind limbs that are longer than its fore limbs. It belongs to the family Leporidae of the order Lagomorpha, and in contrast to hares, possesses 22 instead of 24 pairs of chromosomes. Belgian Hare,New Zealand Rabbit,New Zealand Rabbits,New Zealand White Rabbit,Rabbit,Rabbit, Domestic,Chinchilla Rabbits,NZW Rabbits,New Zealand White Rabbits,Oryctolagus cuniculus,Chinchilla Rabbit,Domestic Rabbit,Domestic Rabbits,Hare, Belgian,NZW Rabbit,Rabbit, Chinchilla,Rabbit, NZW,Rabbit, New Zealand,Rabbits, Chinchilla,Rabbits, Domestic,Rabbits, NZW,Rabbits, New Zealand,Zealand Rabbit, New,Zealand Rabbits, New,cuniculus, Oryctolagus
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000893 Anti-Inflammatory Agents Substances that reduce or suppress INFLAMMATION. Anti-Inflammatory Agent,Antiinflammatory Agent,Agents, Anti-Inflammatory,Agents, Antiinflammatory,Anti-Inflammatories,Antiinflammatories,Antiinflammatory Agents,Agent, Anti-Inflammatory,Agent, Antiinflammatory,Agents, Anti Inflammatory,Anti Inflammatories,Anti Inflammatory Agent,Anti Inflammatory Agents

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T Hayashi, and M Sato, and M Ohki, and T Kishikawa
[Pharmacological studies of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (M73101). (2). Anti-inflammatory activity (author's transl)].
March 1979, Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
T Hayashi, and M Sato, and M Ohki, and T Kishikawa
Metabolism of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (M73101), a new anti-inflammatory agent. II. Species differences of metabolism and excretion.
February 1979, Chemical & pharmaceutical bulletin,
T Hayashi, and M Sato, and M Ohki, and T Kishikawa
[Pharmacological studies of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (M73101). (3). General pharmacological actions (author's transl)].
April 1979, Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
T Hayashi, and M Sato, and M Ohki, and T Kishikawa
[Pharmacological studies of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (M73101). (4). Enzyme induction (author's transl)].
September 1979, Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
T Hayashi, and M Sato, and M Ohki, and T Kishikawa
Pituitary-adrenocortical stimulation and anti-inflammatory actions of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (M73101).
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T Hayashi, and M Sato, and M Ohki, and T Kishikawa
[Pharmacological studies of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (M73101). (1). Analgesic activity (author's transl)].
October 1978, Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
T Hayashi, and M Sato, and M Ohki, and T Kishikawa
[Pharmacological studies of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (M73101). (5) Action of M73101 on the central nervous system (author's transl)].
October 1979, Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
T Hayashi, and M Sato, and M Ohki, and T Kishikawa
[Metabolism of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (M73101), a new anti-inflammatory agent. IV. Plasma concentration and absorption in various animals (author's transl)].
January 1980, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
T Hayashi, and M Sato, and M Ohki, and T Kishikawa
[Studies on pyridazinone derivatives. VII. Synthesis of urinary metabolites of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (M73101) in human (author's transl)].
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