-transparent.png){kind=logo}
The effects of preanesthetic oral cimetidine on gastric fluid pH and volume were studied in 97 infants and children. A dose-response curve was constructed using doses of 2.5, 5.0, 7.5, and 10 mg/kg. The ED50 of cimetidine that produces pH values higher than 2.5 was 3.0 mg/kg, and the ED95 was 7.5 mg/kg. Cimetidine exponentially reduced the volume of gastric fluid. Cimetidine was most effective between one and four hours after oral administration. In children who are at high risk of pulmonary aspiration, we recommend that oral cimetidine, 7.5 mg/kg, be given 1-3 hours preoperatively in order to protect the lungs from the accidental aspiration of acidic gastric secretions.
Related Publications
N Goudsouzian, and
C J Coté, and
L M Liu, and
D F Dedrick
October 1989,
Anesthesiology,
N Goudsouzian, and
C J Coté, and
L M Liu, and
D F Dedrick
June 1984,
Anesthesia and analgesia,
N Goudsouzian, and
C J Coté, and
L M Liu, and
D F Dedrick
March 1983,
Minerva anestesiologica,
N Goudsouzian, and
C J Coté, and
L M Liu, and
D F Dedrick
August 1986,
Anesthesiology,
N Goudsouzian, and
C J Coté, and
L M Liu, and
D F Dedrick
January 1991,
Journal of clinical anesthesia,
N Goudsouzian, and
C J Coté, and
L M Liu, and
D F Dedrick
April 1995,
British journal of anaesthesia,
N Goudsouzian, and
C J Coté, and
L M Liu, and
D F Dedrick
November 1994,
British journal of anaesthesia,
N Goudsouzian, and
C J Coté, and
L M Liu, and
D F Dedrick
June 1987,
British journal of anaesthesia,
N Goudsouzian, and
C J Coté, and
L M Liu, and
D F Dedrick
December 1988,
AANA journal,
N Goudsouzian, and
C J Coté, and
L M Liu, and
D F Dedrick
March 1984,
Masui. The Japanese journal of anesthesiology,
