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A case of Letterer-Siwe revealing the clinical variability of this illness is described. A one and a half year old child with osteoporosis and osteolysis of the sphenoid bone at the level of the sella turcica and eczematous lesions in the retroauricular and cranial region is presented. Cortical steroid and orally administered Methotrexate have been used. Progress is good and possibility of radiating the sphenoid bone lesion with a small field not affecting the hypophysis is considered.
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