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Viloxazine hydrochloride (ICI 58,834, VIVALAN) a chemically novel antidepressant, shows selective inhibition of noradrenaline uptake into mouse heart in vivo and into rat brain in vitro. The noradrenaline uptake inhibitory activity resides primarily in one of the two optically active isomers, and it is suggested that in the conformation adopted for uptake by noradrenaline, the aryl and the amino groups are trans. In a comparison of in vivo and in vitro potency, tri- and tetracyclic antidepressants exhibit a good correlation. However, viloxazine possesses higher in vivo activity than would be expected from in vitro studies. The latter finding cannot be readily explained on the basis of known pharmacokinetic or metabolic factors.
T P Blackburn, and
G A Foster, and
D T Greenwood, and
R Howe
August 1976,
Canadian journal of physiology and pharmacology,
T P Blackburn, and
G A Foster, and
D T Greenwood, and
R Howe
December 2000,
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T P Blackburn, and
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T P Blackburn, and
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T P Blackburn, and
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T P Blackburn, and
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T P Blackburn, and
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R Howe
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T P Blackburn, and
G A Foster, and
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R Howe
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T P Blackburn, and
G A Foster, and
D T Greenwood, and
R Howe
January 1977,
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T P Blackburn, and
G A Foster, and
D T Greenwood, and
R Howe
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