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During the period 1965-1974, 110 patients with stage I malignant melanoma of the extremities were treated by regional isolated perfusion with L-phenylalanine mustard and local excision. In order to study local recurrence and survival, only patients with a primary melanoma Clark Level IV or V and a tumor thickness of more than 1.5 mm were accepted in this study. The determinate survival in patients followed for 5-14 years in 78%; 17% developed positive regional lymph nodes. The local skin recurrence rate was 9% (9 patients); four of these 9 patients simultaneously had distant metastases; the other five patients are alive with NED after retreatment. This series of patients, too, shows that tumor thickness determines the prognosis, both as to local recurrence and as to survival. The mean tumor thickness in the hyperthermically perfused patients was found to clearly exceed that in the normothermically perfused, the mean values being 4.85 mm and 3.87 mm, respectively. Yet local recurrence and regional lymph node metastases proved to be less frequent after hyperthermic than after normothermic perfusion, although the difference was not statistically significant.
H Schraffordt Koops, and
H Beekhuis, and
J Oldhoff, and
J W Oosterhuis, and
E van der Ploeg, and
A Vermey
September 1982,
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete,
H Schraffordt Koops, and
H Beekhuis, and
J Oldhoff, and
J W Oosterhuis, and
E van der Ploeg, and
A Vermey
October 1990,
Nederlands tijdschrift voor geneeskunde,
H Schraffordt Koops, and
H Beekhuis, and
J Oldhoff, and
J W Oosterhuis, and
E van der Ploeg, and
A Vermey
May 1986,
Cancer,
H Schraffordt Koops, and
H Beekhuis, and
J Oldhoff, and
J W Oosterhuis, and
E van der Ploeg, and
A Vermey
April 1993,
Journal of surgical oncology,
H Schraffordt Koops, and
H Beekhuis, and
J Oldhoff, and
J W Oosterhuis, and
E van der Ploeg, and
A Vermey
January 1976,
Cancer,
H Schraffordt Koops, and
H Beekhuis, and
J Oldhoff, and
J W Oosterhuis, and
E van der Ploeg, and
A Vermey
October 1992,
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology,
H Schraffordt Koops, and
H Beekhuis, and
J Oldhoff, and
J W Oosterhuis, and
E van der Ploeg, and
A Vermey
January 1983,
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer,
H Schraffordt Koops, and
H Beekhuis, and
J Oldhoff, and
J W Oosterhuis, and
E van der Ploeg, and
A Vermey
February 1977,
American journal of surgery,
H Schraffordt Koops, and
H Beekhuis, and
J Oldhoff, and
J W Oosterhuis, and
E van der Ploeg, and
A Vermey
January 1992,
World journal of surgery,
H Schraffordt Koops, and
H Beekhuis, and
J Oldhoff, and
J W Oosterhuis, and
E van der Ploeg, and
A Vermey
April 1988,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
