BIOMAT Database Logo BIOMAT Database Logo

Chemical synthesis and adjuvant activity of N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) analogs 1, 2. 1981

K Kamisango, and I Saiki, and Y Tanio, and S Kobayashi, and T Fukuda, and I Sekikawa, and I Azuma, and Y Yamamura

UI MeSH Term Description Entries
D006968 Hypersensitivity, Delayed An increased reactivity to specific antigens mediated not by antibodies but by sensitized T CELLS. Hypersensitivity, Tuberculin-Type,Hypersensitivity, Type IV,Tuberculin-Type Hypersensitivity,Type IV Hypersensitivity,Delayed Hypersensitivity,Delayed Hypersensitivities,Hypersensitivity, Tuberculin Type,Tuberculin Type Hypersensitivity,Tuberculin-Type Hypersensitivities,Type IV Hypersensitivities
D006020 Glycopeptides Proteins which contain carbohydrate groups attached covalently to the polypeptide chain. The protein moiety is the predominant group with the carbohydrate making up only a small percentage of the total weight. Glycopeptide
D006168 Guinea Pigs A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research. Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000119 Acetylmuramyl-Alanyl-Isoglutamine Peptidoglycan immunoadjuvant originally isolated from bacterial cell wall fragments; also acts as pyrogen and may cause arthritis; stimulates both humoral and cellular immunity. Mur-NAc-L-Ala-D-isoGln,Muramyl Dipeptide,Acetylmuramyl Alanyl Isoglutamine,N-Acetyl-Muramyl-L-Alanyl-D-Glutamic-alpha-Amide,N-Acetylmuramyl-L-Alanyl-D-Isoglutamine,Alanyl Isoglutamine, Acetylmuramyl,Dipeptide, Muramyl,Isoglutamine, Acetylmuramyl Alanyl,Mur NAc L Ala D isoGln,N Acetyl Muramyl L Alanyl D Glutamic alpha Amide,N Acetylmuramyl L Alanyl D Isoglutamine
D000276 Adjuvants, Immunologic Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. Immunoactivators,Immunoadjuvant,Immunoadjuvants,Immunologic Adjuvant,Immunopotentiator,Immunopotentiators,Immunostimulant,Immunostimulants,Adjuvant, Immunologic,Adjuvants, Immunological,Immunologic Adjuvants,Immunological Adjuvant,Adjuvant, Immunological,Immunological Adjuvants
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

K Kamisango, and I Saiki, and Y Tanio, and S Kobayashi, and T Fukuda, and I Sekikawa, and I Azuma, and Y Yamamura
Study of immunomodulatory properties of N-acetylmuramyl-L-alanyl-D-isoglutamine and N-acetylglucosaminyl-(beta 1----4)-N-acetylmuramyl-L-alanyl-D-isoglutamine.
January 1991, Biomedical science,
K Kamisango, and I Saiki, and Y Tanio, and S Kobayashi, and T Fukuda, and I Sekikawa, and I Azuma, and Y Yamamura
Mitogenic activity of adjuvant-active N-acetylmuramyl-L-alanyl-D-isoglutamine and its analogues.
June 1977, Biken journal,
K Kamisango, and I Saiki, and Y Tanio, and S Kobayashi, and T Fukuda, and I Sekikawa, and I Azuma, and Y Yamamura
Higher immunoadjuvant activities of N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetylmuramyl-L-alanyl-D-isoglutamine in comparison with N-acetylmuramyl-L-alanyl-D-isoglutamine.
January 1979, Microbiology and immunology,
K Kamisango, and I Saiki, and Y Tanio, and S Kobayashi, and T Fukuda, and I Sekikawa, and I Azuma, and Y Yamamura
Immunoadjuvant effects of the synthetic muramyl-dipeptide (MDP) N-acetylmuramyl-L-alanyl-D-isoglutamine.
October 1978, Zeitschrift fur Immunitatsforschung. Immunobiology,
K Kamisango, and I Saiki, and Y Tanio, and S Kobayashi, and T Fukuda, and I Sekikawa, and I Azuma, and Y Yamamura
Adjuvant activity of synthetic 6-O-"mycoloyl"-N-acetylmuramyl-L-alanyl-D-isoglutamine and related compounds.
June 1978, Infection and immunity,
K Kamisango, and I Saiki, and Y Tanio, and S Kobayashi, and T Fukuda, and I Sekikawa, and I Azuma, and Y Yamamura
[Synthesis and biological activity of aryl S-beta-glycosides of 1-thio-N-acetylmuramyl-L-alanyl-D-isoglutamine].
January 2008, Bioorganicheskaia khimiia,
K Kamisango, and I Saiki, and Y Tanio, and S Kobayashi, and T Fukuda, and I Sekikawa, and I Azuma, and Y Yamamura
Adjuvant activity of mycoloyl derivatives of N-acetylmuramyl-L-alanyl-D-isoglutamine in mice and guinea pigs.
January 1979, Microbiology and immunology,
K Kamisango, and I Saiki, and Y Tanio, and S Kobayashi, and T Fukuda, and I Sekikawa, and I Azuma, and Y Yamamura
In vitro spleen cell responsiveness to various analogs of MDP (N-acetylmuramyl-L-alanyl-D-isoglutamine), a synthetic immunoadjuvant, in MDP high-responder mice.
January 1978, Cellular immunology,
K Kamisango, and I Saiki, and Y Tanio, and S Kobayashi, and T Fukuda, and I Sekikawa, and I Azuma, and Y Yamamura
Synthesis of some new analogs of the immunoadjuvant glycopeptide MDP (N-acetyl-muramyl-L-alanyl-D-isoglutamine).
April 1978, International journal of peptide and protein research,
K Kamisango, and I Saiki, and Y Tanio, and S Kobayashi, and T Fukuda, and I Sekikawa, and I Azuma, and Y Yamamura
Relationship between chemical structure and adjuvant activity of some synthetic analogues of N-acetyl-muramyl-L-alanyl-D-isoglutamine (MDP).
January 1977, Annales d'immunologie,
Copied contents to your clipboard!