Importance of perinatal testosterone in sexual differentiation in the male rat. 1981

F Gogan, and A Slama, and B Bizzini-Koutznetzova, and F Dray, and C Kordon

Testosterone secretion in the male rat was high during the late fetal and immediate postnatal periods. It then showed a rapid decrease 3h after birth and remained low until puberty. Male rats from mothers given daily injections of an antibody to testosterone during the week before delivery displayed an LH peak when they were adult, orchidectomized and implanted with oestradiol. However, the amplitude of the peak was far smaller than in female rats from the same mothers treated in the same manner. Thus, the critical period during which testosterone triggers hypothalamic sexual differentiation is very close to birth, possibly starting at the end of the fetal period.

UI MeSH Term Description Entries
D007986 Luteinizing Hormone A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity. ICSH (Interstitial Cell Stimulating Hormone),Interstitial Cell-Stimulating Hormone,LH (Luteinizing Hormone),Lutropin,Luteoziman,Luteozyman,Hormone, Interstitial Cell-Stimulating,Hormone, Luteinizing,Interstitial Cell Stimulating Hormone
D008297 Male Males
D010053 Ovary The reproductive organ (GONADS) in female animals. In vertebrates, the ovary contains two functional parts: the OVARIAN FOLLICLE for the production of female germ cells (OOGENESIS); and the endocrine cells (GRANULOSA CELLS; THECA CELLS; and LUTEAL CELLS) for the production of ESTROGENS and PROGESTERONE. Ovaries
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D002369 Castration Surgical removal or artificial destruction of gonads. Gonadectomy,Castrations,Gonadectomies
D005260 Female Females
D005312 Fetal Blood Blood of the fetus. Exchange of nutrients and waste between the fetal and maternal blood occurs via the PLACENTA. The cord blood is blood contained in the umbilical vessels (UMBILICAL CORD) at the time of delivery. Cord Blood,Umbilical Cord Blood,Blood, Cord,Blood, Fetal,Blood, Umbilical Cord,Bloods, Cord,Bloods, Fetal,Bloods, Umbilical Cord,Cord Blood, Umbilical,Cord Bloods,Cord Bloods, Umbilical,Fetal Bloods,Umbilical Cord Bloods
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012733 Sex Differentiation The process in developing sex- or gender-specific tissue, organ, or function after SEX DETERMINATION PROCESSES have set the sex of the GONADS. Major areas of sex differentiation occur in the reproductive tract (GENITALIA) and the brain. Differentiation, Sex,Sexual Differentiation,Differentiation, Sexual

Related Publications

F Gogan, and A Slama, and B Bizzini-Koutznetzova, and F Dray, and C Kordon
January 1986, Reproduction, nutrition, developpement,
F Gogan, and A Slama, and B Bizzini-Koutznetzova, and F Dray, and C Kordon
June 1978, Behavioral biology,
F Gogan, and A Slama, and B Bizzini-Koutznetzova, and F Dray, and C Kordon
January 1974, The Journal of clinical endocrinology and metabolism,
F Gogan, and A Slama, and B Bizzini-Koutznetzova, and F Dray, and C Kordon
December 2000, Toxicological sciences : an official journal of the Society of Toxicology,
F Gogan, and A Slama, and B Bizzini-Koutznetzova, and F Dray, and C Kordon
December 1981, Journal of biochemistry,
F Gogan, and A Slama, and B Bizzini-Koutznetzova, and F Dray, and C Kordon
February 1977, Hormones and behavior,
F Gogan, and A Slama, and B Bizzini-Koutznetzova, and F Dray, and C Kordon
October 1985, Physiology & behavior,
F Gogan, and A Slama, and B Bizzini-Koutznetzova, and F Dray, and C Kordon
February 1989, Brain research,
F Gogan, and A Slama, and B Bizzini-Koutznetzova, and F Dray, and C Kordon
March 2004, Toxicological sciences : an official journal of the Society of Toxicology,
F Gogan, and A Slama, and B Bizzini-Koutznetzova, and F Dray, and C Kordon
September 1978, Biology of reproduction,
Copied contents to your clipboard!