Biomaterial Database

Effect of magnesium deficiency on lipid metabolism in rats fed a high carbohydrate diet. 1981

Y Rayssiguier, and E Gueux, and D Weiser

The effects of acute magnesium deficiency on lipid metabolism were examined in weaning rats fed a high carbohydrate diet containing starch or sucrose for 8 days. Rats were killed after the feeding period. In plasma, magnesium deficiency increased triglyceride and free cholesterol levels and decreased esterified cholesterol levels. Rats fed a magnesium-deficient diet containing sucrose showed particularly high triglyceride plasma levels. In liver, magnesium-deficient rats fed sucrose showed a significant increase in triglycerides, lactate and alpha-glycerophosphate and a significant decrease in glycogen. Changes in triglycerides and glycogen in the liver of magnesium-deficient rats fed starch were not significant. In sucrose-fed rats, serum lipoproteins were isolated by ultracentrifugation. With magnesium deficiency, triglycerides were significantly increased in the very low density lipoprotein (VLDL) and low density lipoprotein (LDL) fractions and cholesterol levels were increased in the VLDL and LDL and significantly lower in the high density lipoprotein (HDL) fractions. The detrimental effect of severe magnesium deficiency associated particularly with a high carbohydrate diet content and more especially with a sucrose diet is discussed.

UI	MeSH Term	Description	Entries
D007773	Lactates	Salts or esters of LACTIC ACID containing the general formula CH3CHOHCOOR.
D008074	Lipoproteins	Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. They are spherical particles consisting of a hydrophobic core of TRIGLYCERIDES and CHOLESTEROL ESTERS surrounded by a layer of hydrophilic free CHOLESTEROL; PHOSPHOLIPIDS; and APOLIPOPROTEINS. Lipoproteins are classified by their varying buoyant density and sizes.	Circulating Lipoproteins,Lipoprotein,Lipoproteins, Circulating
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008275	Magnesium Deficiency	A nutritional condition produced by a deficiency of magnesium in the diet, characterized by anorexia, nausea, vomiting, lethargy, and weakness. Symptoms are paresthesias, muscle cramps, irritability, decreased attention span, and mental confusion, possibly requiring months to appear. Deficiency of body magnesium can exist even when serum values are normal. In addition, magnesium deficiency may be organ-selective, since certain tissues become deficient before others. (Harrison's Principles of Internal Medicine, 12th ed, p1936)	Deficiency, Magnesium,Deficiencies, Magnesium,Magnesium Deficiencies
D008297	Male		Males
D002784	Cholesterol	The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.	Epicholesterol
D002788	Cholesterol Esters	Fatty acid esters of cholesterol which constitute about two-thirds of the cholesterol in the plasma. The accumulation of cholesterol esters in the arterial intima is a characteristic feature of atherosclerosis.	Cholesterol Ester,Cholesteryl Ester,Cholesteryl Esters,Ester, Cholesterol,Ester, Cholesteryl,Esters, Cholesterol,Esters, Cholesteryl
D004040	Dietary Carbohydrates	Carbohydrates present in food comprising digestible sugars and starches and indigestible cellulose and other dietary fibers. The former are the major source of energy. The sugars are in beet and cane sugar, fruits, honey, sweet corn, corn syrup, milk and milk products, etc.; the starches are in cereal grains, legumes (FABACEAE), tubers, etc. (From Claudio & Lagua, Nutrition and Diet Therapy Dictionary, 3d ed, p32, p277)	Carbohydrates, Dietary,Carbohydrate, Dietary,Dietary Carbohydrate
D005994	Glycerophosphates	Any salt or ester of glycerophosphoric acid.	Glycerolphosphate,Glycerophosphate,Calcium Glycerophosphate,Glycerolphosphates,Glycerophosphate, Calcium
D006003	Glycogen